Clinical trial with escalating doses of the antiepidermal growth factor receptor humanized monoclonal antibody EMD 72 000 in patients with advanced squamous cell carcinoma of the larynx and hypopharynx
- Author
- BIER, Henning1 ; HOFFMANN, Thomas1 ; HAUSER, Ulrich1 ; WINK, Michael2 ; ÖCHLER, Martin2 ; KOVAR, Andreas3 ; MÜSER, Matthias3 ; KNECHT, Reinald2
[1] Department of Otorhinolaryngology/Head and Neck Surgery, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany
[2] Department of Otorhinolaryngology/Head and Neck Surgery, Johann-Wolfgang-Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
[3] Merck KGaA, Frankfurter Strasse 250, 64271 Darmstadt, Germany - Source
Cancer chemotherapy and pharmacology. 2001, Vol 47, Num 6, pp 519-524 ; ref : 524 ref
- CODEN
- CCPHDZ
- ISSN
- 0344-5704
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Springer, Berlin
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Anticorps monoclonal Carcinome épidermoïde Dose croissante Dose maximale Efficacité traitement Essai clinique phase I Facteur croissance épiderme Homme Hypopharynx Immunothérapie Larynx Pharmacocinétique Récepteur facteur croissance Stade avancé Toxicité Traitement Tumeur maligne Voie intraveineuse Anticorps humanisé EMD 72000 Larynx pathologie ORL pathologie Pharynx pathologie
- Keyword (en)
- Antineoplastic agent Monoclonal antibody Squamous cell carcinoma Increasing dose Maximal dose Treatment efficiency Phase I trial Epidermal growth factor Human Hypopharynx Immunotherapy Larynx Pharmacokinetics Growth factor receptor Advanced stage Toxicity Treatment Malignant tumor Intravenous administration Humanized antibody Larynx disease ENT disease Pharynx disease
- Keyword (es)
- Anticanceroso Anticuerpo monoclonal Carcinoma epidermoide Dosis creciente Dosis máxima Eficacia tratamiento Ensayo clínico fase I Factor crecimiento epidermi Hombre Hipofaringe Inmunoterapia Laringe Farmacocinética Receptor factor crecimiento Estadio avanzado Toxicidad Tratamiento Tumor maligno Vía intravenosa Laringe patología ORL patología Faringe patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R03 Immunotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1075990
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s002800000270 
https://dx.doi.org/10.1007/s002800000270
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