Assessing the emetic potential of PDE4 inhibitors in rats
- Author
- ROBICHAUD, A1 ; SAVOIE, C1 ; STAMATIOU, P. B1 ; LACHANCE, N1 ; JOLICOEUR, P1 ; RASORI, R1 ; CHAN, C. C1
[1] Merck Frosst Centre for Therapeutic Research, P.O. Box 1005 Pointe-Claire, Dorval (Qc) H9R 4P8, Canada - Source
British journal of pharmacology. 2002, Vol 135, Num 1, pp 113-118 ; ref : 26 ref
- CODEN
- BJPCBM
- ISSN
- 0007-1188
- Scientific domain
- Pharmacology drugs
- Publisher
- Nature Publishing, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anesthésique général Animal Association médicamenteuse Emétique Encéphale Inhibiteur enzyme Interaction médicamenteuse Mécanisme action Phosphoric diester hydrolases Rat Récepteur tachykinine NK1 Récepteur α2-adrénergique Système nerveux central Toxicité Voie souscutanée Vomissement Appareil digestif pathologie Enzyme Esterases Hydrolases Mammalia Rodentia Vertebrata
- Keyword (en)
- General anesthetic Animal Drug combination Emetic Brain (vertebrata) Enzyme inhibitor Drug interaction Mechanism of action Phosphoric diester hydrolases Rat NK1 Tachykinin receptor α2-Adrenergic receptor Central nervous system Toxicity Subcutaneous administration Vomiting Digestive diseases Enzyme Esterases Hydrolases Mammalia Rodentia Vertebrata
- Keyword (es)
- Anestésico general Animal Asociación medicamentosa Emético Encéfalo Inhibidor enzima Interacción medicamentosa Mecanismo acción Phosphoric diester hydrolases Rata Receptor taquikinina NK1 Receptor α2-adrenérgico Sistema nervioso central Toxicidad Vía subcutánea Vómito Aparato digestivo patología Enzima Esterases Hydrolases Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02U Drug toxicity and drugs side effects treatment / 002B02U04 Toxicity: digestive system
- Discipline
- Drugs toxicity and drug intoxications Toxicology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 13845328
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.bjp.0704457 
https://dx.doi.org/10.1038/sj.bjp.0704457
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