Synthesis, pharmacology and pharmacokinetics of 3-(4-aryl-piperazin-1-ylalkyl)-uracils as uroselective α1A-antagonists
- Author
- LOPEZ, F. J1 ; ARIAS, L1 ; PADILLA, F1 ; PEREZ-MEDRANO, A1 ; QUINTERO, C1 ; ROMERO, M1 ; SANDOVAL, L1 ; SMITH, S. A1 ; WILLIAMS, T. J1 ; BLUE, D. R1 ; CHAN, R1 ; CLARKE, D. E1 ; ELWORTHY, T. R1 ; FORD, A. P. D. W1 ; GUZMAN, A1 ; JAIME-FIGUEROA, S1 ; JASPER, J. R1 ; MORGANS, D. J1
[1] Roche Bioscience, 3431 Hillview Ave, Palo Alto, CA 94304, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 11, pp 1873-1878, 6 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antagoniste Biodisponibilité Chien Cycle 6 chaînons Dose unique Halogénoéther Hétérocycle azote In vitro Métabolisme Pharmacocinétique Pipérazine dérivé Pyrimidine dérivé Relation structure activité Récepteur α1A-adrénergique Singe Synthèse chimique Voie intraveineuse Voie orale Pyrimidine-2,4-dione5,6-dihydro-5,6-dihydroxy-3-[3-(4-[4-fluoro-2-(2,2,2-trifluoroéthoxy)phényl]pipérazino)propyl]-5-méthyl RO 1104253 RO 700004 Thymine3-[3-(4-[4-fluoro-2-(2,2,2-trifluoroéthoxy)phényl]pipérazino)propyl] Carnivora Fissipedia Fluor Composé organique Mammalia Primates Vertebrata
- Keyword (en)
- Animal Antagonist Bioavailability Dog Six membered ring Single dose Haloether Nitrogen heterocycle In vitro Metabolism Pharmacokinetics Piperazine derivatives Pyrimidine derivatives Structure activity relation α1A-adrenergic receptor Monkey Chemical synthesis Intravenous administration Oral administration Carnivora Fissipedia Fluorine Organic compounds Mammalia Primates Vertebrata
- Keyword (es)
- Animal Antagonista Biodisponibilidad Perro Ciclo 6 eslabones Dosis única Haloéter Heterociclo nitrógeno In vitro Metabolismo Farmacocinética Piperazina derivado Pirimidina derivado Relación estructura actividad Receptor α1A-adrenérgico Mono Síntesis química Vía intravenosa Vía oral Carnivora Fissipedia Fluor Compuesto orgánico Mammalia Primates Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02I Urinary system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14771395
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0960-894X(03)00305-6 
https://dx.doi.org/10.1016/S0960-894X(03)00305-6
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