A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic β-sulfonyl-endoperoxides
- Author
- BACHI, Mario D1 ; KORSHIN, Edward E1 ; HOOS, Roland1 ; SZPILMAN, Alex M1 ; PLOYPRADITH, Poonsakdi2 ; SUJI XIE3 ; SHAPIRO, Theresa A3 ; POSNER, Gary H2
[1] Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
[2] Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, United States
[3] Division of Clinical Pharmacology, Department of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, United States - Source
Journal of medicinal chemistry (Print). 2003, Vol 46, Num 12, pp 2516-2533, 18 p ; ref : 53 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acylate Animal Antipaludique Antiparasitaire Composé bicyclique Endoperoxyde Hétérocycle oxygène In vitro In vivo Peroxyde organique Plasmodium berghei Plasmodium falciparum Plasmodium yoelii Relation structure activité Souris Sulfone Synthèse chimique 2,3-Dioxabicyclo[3.3.1]nonan-7-ol(4-benzènesulfonylméthyl-4,7-diméthyl) acétate 2,3-Dioxabicyclo[3.3.1]nonane(4-benzènesulfonylméthyl-7-benzyloxy-4,7-diméthyl) Dioxabicyclononane Apicomplexa Mammalia Protozoa Rodentia Vertebrata
- Keyword (en)
- Acylate Animal Antimalarial Parasiticid Bicyclic compound Endoperoxide Oxygen heterocycle In vitro In vivo Organic peroxide Plasmodium berghei Plasmodium falciparum Plasmodium yoelii Structure activity relation Mouse Sulfone Chemical synthesis Apicomplexa Mammalia Protozoa Rodentia Vertebrata
- Keyword (es)
- Acilato Animal Antipalúdico Antiparasitario Compuesto bicíclico Endoperóxido Heterociclo oxígeno In vitro In vivo Peróxido orgánico Plasmodium berghei Plasmodium falciparum Plasmodium yoelii Relación estructura actividad Ratón Sulfona Síntesis química Apicomplexa Mammalia Protozoa Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 14843786
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm020584a 
https://dx.doi.org/10.1021/jm020584a
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