VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
- Author
- LAMBRECHTS, Diether1 ; STORKEBAUM, Erik1 ; AL-CHALABI, Ammar5 ; BORNES, Stephanie6 ; MUSSON, Rhiannon4 ; HANSEN, Valerie5 ; BECKMAN, Lars3 ; ADOLFSSON, Rolf7 ; HARDEV SINGH PALL4 ; PRATS, Hervé6 ; VERMEIRE, Severine1 ; RUTGEERTS, Paul1 ; MORIMOTO, Masafumi1 ; KATAYAMA, Shigehiro8 ; AWATA, Takuya8 ; LEIGH, Nigel5 ; LANG-LAZDUNSKI, Loïc9 ; DEWERCHIN, Mieke1 ; SHAW, Christopher5 ; MOONS, Lieve1 ; VLIETINCK, Robert1 10 ; MORRISON, Karen E4 ; ROBBERECHT, Wim1 ; DEL-FAVERO, Jurgen2 ; VAN BROECKHOVEN, Christine2 ; COLLEN, Désiré1 ; ANDERSEN, Peter M3 ; CARMELIET, Peter1 ; DESMET, Frederik1 ; MARKLUND, Stefan L3 ; WYNS, Sabine1 ; THIJS, Vincent1 ; ANDERSSON, Jörgen3 ; VAN MARION, Ingrid4
[1] The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology and Departments of Neurology and Internal Medicine, University Hospital Gasthuisberg, KU Leuven, Leuven, 3000, Belgium
[2] Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, 2610 Antwerpen, Belgium
[3] Department of Neurology, Umea University Hospital, and Institute of Clinical Neuroscience and Medical Genetics, Umea University, 901 85 Umeå, Sweden
[4] Department of Neurology, The Medical School, University of Birmingham, Edgbaston, B15 2TT, United Kingdom
[5] Departments of Neurology and Medical and Molecular Genetics, Guy's, King's and St. Thomas' School of Medicine and Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom
[6] INSERM 397, Endocrinologie et Communication Cellulaire, Institut Fédératif de Recherche Louis Bugnard, CHU Rangueil, 31403 Toulouse, France
[7] Department of Clinical Sciences, Division of Psychiatry, Umea University, Umea, Sweden
[8] 4th Department of Medicine, Saitama Medical School, Moroyama, Iruma-gun, Saitama 350-0495, Japan
[9] Service de Chirurgie Thoracique, Hôpital Européen Georges Pompidou, 75015 Paris, France
[10] Department of Population Genetics, Genomics & Bioinformatics, University Maastricht, 6200 MD Maastricht, Netherlands - Source
Nature genetics. 2003, Vol 34, Num 4, pp 383-394, 12 p ; ref : 50 ref
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Facteur croissance endothélium vasculaire Homme Ischémie Mort Neurone moteur Sclérose latérale amyotrophique Souris Appareil circulatoire pathologie Maladie dégénérative Mammalia Moelle épinière pathologie Rodentia Système nerveux central pathologie Système nerveux pathologie Vertebrata
- Keyword (en)
- Vascular endothelium growth factor Human Ischemia Death Motor neuron Amyotrophic lateral sclerosis Mouse Cardiovascular disease Degenerative disease Mammalia Spinal cord disease Rodentia Central nervous system disease Nervous system diseases Vertebrata
- Keyword (es)
- Factor crecimiento endotelio vascular Hombre Isquemia Muerte Neurona motora Esclerosis lateral amiotrófica Ratón Aparato circulatorio patología Enfermedad degenerativa Mammalia Médula espinal patología Rodentia Sistema nervosio central patología Sistema nervioso patología Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A30 Embryology: invertebrates and vertebrates. Teratology / 002A30D Molecular embryology
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17A Nervous system (semeiology, syndromes) / 002B17A07 Cerebrospinal fluid. Meninges. Spinal cord
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17G Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
- Discipline
- Embryology : invertebrates and vertebrates. Teratology Neurology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15048557
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng1211 
https://dx.doi.org/10.1038/ng1211
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