Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome following fluoropyrimidine-based chemotherapy for metastatic colorectal cancer
- Author
- ICHIKAWA, W1 ; UETAKE, H2 ; SHIROTA, Y2 ; YAMADA, H2 ; TAKAHASHI, T1 ; NIHEI, Z1 ; SUGIHARA, K2 ; SASAKI, Y3 ; HIRAYAMA, R1
[1] Second Department of Surgery, Saitama Medical School, 38, Moro-Hongo, Moroyama-cho, Iruma-gun, Saitama 350-0495, Japan
[2] Department of Digestive Surgery, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
[3] Department of Clinical Oncology, Saitama Medical School, 38, Moro-Hongo, Moroyama-cho, Iruma-gun, Saitama 350-0495, Japan - Source
British journal of cancer. 2003, Vol 89, Num 8, pp 1486-1492, 7 p ; ref : 41 ref
- CODEN
- BJCAAI
- ISSN
- 0007-0920
- Scientific domain
- Medical oncology
- Publisher
- Nature Publishing Group, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- dihydropyrimidine dehydrogenase fluoropyrimidine-based chemotherapy metastatic colorectal cancer orotate phosphoribosyl transferase
- Keyword (fr)
- Anticancéreux Antimétabolite Association médicamenteuse Cancer colorectal Chimiothérapie Dihydropyrimidine dehydrogenase (NADP+) Expression génique Fluoropyrimidine dérivé Folinate de calcium Homme Orotate phosphoribosyltransferase Pronostic Pyrimidine dérivé Ratio Stade avancé Traitement Tégafur Uracile Appareil digestif pathologie Côlon pathologie Enzyme Glycosyltransferases Génétique Intestin pathologie Oxidoreductases Pentosyltransferases Rectum pathologie Transferases Tumeur maligne
- Keyword (en)
- Antineoplastic agent Antimetabolic Drug combination Colorectal cancer Chemotherapy Dihydropyrimidine dehydrogenase (NADP+) Gene expression Fluoropyrimidine derivatives Calcium folinate Human Orotate phosphoribosyltransferase Prognosis Pyrimidine derivatives Ratio Advanced stage Treatment Tegafur Uracil Digestive diseases Colonic disease Enzyme Glycosyltransferases Genetics Intestinal disease Oxidoreductases Pentosyltransferases Rectal disease Transferases Malignant tumor
- Keyword (es)
- Anticanceroso Antimetabólito Asociación medicamentosa Cancer de colon y recto Quimioterapia Dihydropyrimidine dehydrogenase (NADP+) Expresión genética Fluoropirimidina derivado Folinato cálcico Hombre Orotate phosphoribosyltransferase Pronóstico Pirimidina derivado Ratio Estadio avanzado Tratamiento Tegafur Uracilo Aparato digestivo patología Colón patología Enzima Glycosyltransferases Genética Intestino patología Oxidoreductases Pentosyltransferases Recto patología Transferases Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15212760
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.bjc.6601335 
https://dx.doi.org/10.1038/sj.bjc.6601335
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