Kinetic isotope effects on the rate-limiting step of heme oxygenase catalysis indicate concerted proton transfer/heme hydroxylation
- Author
- DAVYDOV, Roman1 ; MATSUI, Toshitaka2 ; FUJII, Hiroshi3 ; IKEDA-SAITO, Masao2 4 ; HOFFMAN, Brian M1
[1] Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States
[2] Institute for Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira, Aoba, Sendai 980-8577, Japan
[3] Institute for Molecular Science and Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki 444-8585, Japan
[4] Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4970, United States - Source
Journal of the American Chemical Society. 2003, Vol 125, Num 52, pp 16208-16209, 2 p
- CODEN
- JACSAT
- ISSN
- 0002-7863
- Scientific domain
- Biochemistry, molecular biology, biophysics; Chemistry; Organic chemistry; Atomic molecular physics
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Catalyse enzymatique Constante vitesse Conversion chimique Effet isotopique cinétique Fer Complexe Heme oxygenase (decyclizing) Hème Mécanisme réaction Métalloprotéine Paramètre cinétique Réaction catalytique Spectrométrie RPE Transfert proton Enzyme Oxidoreductases
- Keyword (en)
- Enzymatic catalysis Rate constant Chemical conversion Kinetic isotope effect Iron Complexes Heme oxygenase (decyclizing) Heme Reaction mechanism Metalloproteins Kinetic parameter Catalytic reaction EPR spectrometry Proton transfer Enzyme Oxidoreductases
- Keyword (es)
- Catálisis enzimática Constante velocidad Conversión química Efecto isotópico cinético Hierro Complejo Heme oxygenase (decyclizing) Heme Mecanismo reacción Metaloproteina Parámetro cinético Reacción catalítica Espectrometría RPE Transferencia protón Enzima Oxidoreductases
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A03 Molecular biophysics / 002A03E Physical chemistry in biology / 002A03E01 Mechanisms. Catalysis. Electron transfer. Models
- Discipline
- Molecular biophysics
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15392091
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/ja038923s 
https://dx.doi.org/10.1021/ja038923s
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