In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
- Author
- VASSILEV, Lyubomir T1 ; VU, Binh T2 ; FOTOUHI, Nader2 ; LIU, Emily A2 ; GRAVES, Bradford2 ; CARVAJAL, Daisy1 ; PODLASKI, Frank1 ; FILIPOVIC, Zoran1 ; KONG, Norman2 ; KAMMLOTT, Ursula2 ; LUKACS, Christine2 ; KLEIN, Christian3
[1] Department of Discovery Oncology, Roche Research Center, Hoffmann-La Roche, Inc., Nutley, NJ 07110, United States
[2] Department of Chemistry, Roche Research Center, Hoffmann-La Roche, Inc., Nutley, NJ 07110, United States
[3] Pharma Research, Roche Diagnostics GmbH, 82372 Penzberg, Germany - Source
Science (Washington, D.C.). 2004, Vol 303, Num 5659, pp 844-848, 5 p
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antagoniste Apoptose Cellule tumorale Complexe Composé Cycle cellulaire Homme Hétérogreffe In vivo Molécule Multiplication cellulaire Protéine p53 Souris Traitement Tumeur maligne Greffe Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Antagonist Apoptosis Tumor cell Complexes Compounds Cell cycle Human Heterograft In vivo Molecules Cell proliferation p53 Protein Mouse Treatment Malignant tumor Graft Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Antagonista Apoptosis Célula tumoral Complejo Compuesto Ciclo celular Hombre Heteroinjerto In vivo Molécula Multiplicación celular Proteína p53 Ratón Tratamiento Tumor maligno Injerto Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04G Tumor cell / 002B04G01 General aspects (metabolism, cell proliferation, established cell line...)
- Discipline
- Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15477808
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1126/science.1092472 
https://dx.doi.org/10.1126/science.1092472
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