Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line
- Author
- ABAL, Miguel1 ; BRAS-GONCALVES, Rui2 ; JUDDE, Jean-Gabriel2 ; FSIHI, Hafida3 ; DE CREMOUX, Patricia1 ; LOUVARD, Daniel; MAGDELENAT, Henri1 ; ROBINE, Sylvie3 4 ; POUPON, Marie-France2 4
[1] Transfer Laboratory, Institut Curie-CNRS, Paris 75248, France
[2] Metabolic alterations and cancer therapy, UMR 147, Institut Curie-CNRS, rue d'Ulm, Paris 75248, France
[3] Morphogenesis and intracellular signalling, UMR 144, Institut Curie-CNRS, Paris 75248, France
[4] Tumor Biology Department, Medical Section, Institute Curie-CNRS, Paris 75248, France - Source
Oncogene (Basingstoke). 2004, Vol 23, Num 9, pp 1737-1744, 8 p ; ref : 32 ref
- ISSN
- 0950-9232
- Scientific domain
- Cell biology, histology; Medical oncology; Genetics
- Publisher
- Nature Publishing, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- CYC-202 Roscovitine cdk-inhl colorectal cancer irinotecan p53-dependent sensitivity
- Keyword (fr)
- Anticancéreux Cancer colorectal Carcinogenèse Gène TP53 Gène suppresseur tumeur Homme Inhibition Irinotécan Lignée cellulaire Sensibilité Cancer du côlon Cyclin-dependent protein kinase Appareil digestif pathologie Côlon pathologie Intestin pathologie Rectum pathologie Tumeur maligne
- Keyword (en)
- Antineoplastic agent Colorectal cancer Carcinogenesis TP53 Gene Tumor suppressor gene Human Inhibition Irinotecan Cell line Sensitivity Colon cancer Cyclin-dependent protein kinase Digestive diseases Colonic disease Intestinal disease Rectal disease Malignant tumor
- Keyword (es)
- Anticanceroso Cancer de colon y recto Carcinogénesis Gen TP53 Gen supresor tumor Hombre Inhibición Irinotecán Línea celular Sensibilidad Cáncer del colon Aparato digestivo patología Colón patología Intestino patología Recto patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04H Cell physiology / 002A04H04 Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen Molecular and cell biology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15597549
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.onc.1207299 
https://dx.doi.org/10.1038/sj.onc.1207299
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