Simultaneous central nervous system distribution and pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats
- Author
- CHENEL, Marylore1 2 ; MARCHAND, Sandrine1 ; DUPUIS, Antoine1 3 ; LAMARCHE, Isabelle1 ; PAQUEREAU, Joël4 ; PARIAT, Claudine1 ; COUET, William1
[1] EE Médicaments anti-infectieux et barrière hémato-encéphalique, PBS, Faculté de Médecine & Pharmacie, 40 avenue du Recteur Pineau, 86022 Poitiers, France
[2] Laboratoire de Pharmacocinétique, PBS, CHU La Milétrie, 86022 Poitiers, France
[3] Pharmacie Centrale, CHU La Milétrie, 86022 Poitiers, France
[4] Equipe Sommeil: Attention et Respiration, PBS, Faculté de Médecine & Pharmacie, 86022 Poitiers, France - Source
British journal of pharmacology. 2004, Vol 142, Num 2, pp 323-330, 8 p ; ref : 18 ref
- CODEN
- BJPCBM
- ISSN
- 0007-1188
- Scientific domain
- Pharmacology drugs
- Publisher
- Nature Publishing, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Microdialysis PK-PD modelling electroencephalogram fluoroquinolones rat seizures
- Keyword (fr)
- Animal Antibactérien Distribution Electroencéphalographie Epilepsie Fluoroquinolone dérivé Microdialyse Norfloxacine Rat Relation pharmacocinétique pharmacodynamie Système nerveux central Electrophysiologie Encéphale pathologie Mammalia Quinolone dérivé Rodentia Système nerveux central pathologie Système nerveux pathologie Vertebrata
- Keyword (en)
- Animal Antibacterial agent Distribution Electroencephalography Epilepsy Fluoroquinolone derivatives Microdialysis Norfloxacin Rat Pharmacokinetic pharmacodynamic relationship Central nervous system Electrophysiology Cerebral disorder Mammalia Quinolone derivatives Rodentia Central nervous system disease Nervous system diseases Vertebrata
- Keyword (es)
- Animal Antibacteriano Distribución Electroencefalografía Epilepsia Fluoroquinolone derivado Microdiálisis Norfloxacino Rata Relación farmacocinética farmacodinamia Sistema nervioso central Electrofisiología Encéfalo patología Mammalia Quinolone derivado Rodentia Sistema nervosio central patología Sistema nervioso patología Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15773997
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.bjp.0705748 
https://dx.doi.org/10.1038/sj.bjp.0705748
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