Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation
- Author
- HOPKINS, Corey R1 ; NEUENSCHWANDER, Kent1 ; MAIGNAN, Sebastien4 ; MATHIEU, Magali4 ; SCOTESE, Anthony1 ; JACKSON, Sharon1 ; NIEDUZAK, Thaddeus1 ; PAULS, Henry1 ; GUYAN LIANG2 ; SIDES, Keith3 ; CRAMER, Dona3 ; CAIRNS, Jennifer3
[1] Department of Medicinal Chemistry, Drug Innovation and Approval, Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, United States
[2] Department of Medicinal Chemistry/Molecular Modeling, Drug Innovation and Approval, Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, United States
[3] Department of Molecular Validation and Cell Biology, Drug Innovation and Approval, Aventis Pharmaceuticals, Route 202-206, Bridgewater, NJ 08807, United States
[4] Department of Structural Biology, Aventis Pharma, Vitry 94403, France - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 19, pp 4819-4823, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Inhibiteur enzyme Pyrazine dérivé Synthèse chimique Tryptase Pyrazinone dérivé Enzyme Hydrolases Peptidases Serine endopeptidases
- Keyword (en)
- Biological activity Enzyme inhibitor Pyrazine derivatives Chemical synthesis Tryptase Enzyme Hydrolases Peptidases Serine endopeptidases
- Keyword (es)
- Actividad biológica Inhibidor enzima Pirazina derivado Síntesis química Tryptase Enzima Hydrolases Peptidases Serine endopeptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16101723
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.07.051 
https://dx.doi.org/10.1016/j.bmcl.2004.07.051
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