Synthesis of polyhydroxylated piperidines and evaluation as glycosidase inhibitors
- Author
- TITE, Tony1 ; LALLEMAND, Marie-Christine1 ; POUPON, Erwan1 ; KUNESCH, Nicole1 ; TILLEQUIN, Francois1 ; GRAVIER-PELLETIER, Christine2 ; LE MERRER, Yves2 ; HUSSON, Henri-Philippe3
[1] Laboratoire de Pharmacognosie, Faculté des Sciences Pharmaceutiques et Biologiques, UMR 8638 associée au CNRS et à l'Université René Descartes, 4, A venue de l'Observatoire, 75270 Paris, France
[2] Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 associée au CNRS et à l'Université René Descartes, 45, rue des Saints-Pères, 75270 Paris, France
[3] Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, UMR 8638 associée au CNRS et à l'Université René Descartes, 4, Avenue de l'Observatoire, 75270 Paris, France - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 19, pp 5091-5097, 7 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Aminoalcool Aminoéther Composé bicyclique Hétérocycle oxygène azote In vitro Inhibiteur enzyme Nitrile Relation structure activité Sulfure organique Synthèse chimique α-Glucosidase α-L-Fucosidase α-Mannosidase Iminoalditol Nojirimycine(2-désoxy) Oxazolo[3,2-a]pyridine-5-carbonitrile(3-benzylsulfanylméthyl-perhydro-6,7,8-trihydroxy) Oxazolopyridine Pipéridine-2-méthanol dérivé Enzyme Glycosidases Hydrolases O-Glycosidases
- Keyword (en)
- Aminoalcohol Aminoether Bicyclic compound Oxygen nitrogen heterocycle In vitro Enzyme inhibitor Nitrile Structure activity relation Organic sulfide Chemical synthesis α-Glucosidase α-L-Fucosidase α-Mannosidase Enzyme Glycosidases Hydrolases O-Glycosidases
- Keyword (es)
- Aminoalcohol Aminoeter Compuesto bicíclico Heterociclo oxígeno nitrógeno In vitro Inhibidor enzima Nitrilo Relación estructura actividad Sulfuro orgánico Síntesis química α-Glucosidase α-L-Fucosidase α-Mannosidase Enzima Glycosidases Hydrolases O-Glycosidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02E Enzymes and enzyme inhibitors / 002A02E04 Hydrolases
- Discipline
- Analytical, structural and metabolic biochemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16115261
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.07.039 
https://dx.doi.org/10.1016/j.bmc.2004.07.039
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