Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases
- Author
- MENG, Charles Q1 ; SOMERS, Patricia K1 ; HILL, Russell R1 ; MARINO, Elaine M1 ; SUEN, Ki-Ling1 ; LUCHOOMUN, Jayraz1 ; KUNSCH, Charles1 ; LANDERS, Laura K1 ; STEFANOPOULOS, Dimitria1 ; HOWARD, Randy B1 ; SUNDELL, Cynthia L1 ; SAXENA, Uday1 ; HOONG, Lee K1 ; WASSERMAN, Martin A2 ; SIKORSKI, James A2 ; ZHENG, X. Sharon1 ; ZHIHONG YE1 ; WORSENCROFT, Kimberly J1 ; SIMPSON, Jacob E1 ; HOTEMA, Martha R1 ; WEINGARTEN, M. David1 ; MACDONALD, Mathew L1
[1] AtheroGenics, Inc., 8995 Westside Parkway, Alpharetta, Georgia 30004, United States
[2] AtheroGenics, Inc., 8995 Westside Parkway, Alpharetta, Georgia 30004, United States - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 25, pp 6420-6432, 13 p ; ref : 26 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antiinflammatoire Antioxydant Chronique Composé benzénique Cytokine Dithioacétal In vitro In vivo Inhibiteur Lipophilie Maladie inflammatoire Phénols Propriété physicochimique Protéine CAM Protéine VCAM1 Relation dose réponse Relation structure activité Synthèse chimique Triol Butane-1,2,3-triol(4-[2,6-di-t-butyl-4-(1-[3,5-di-t-butyl-4-hydroxyphénylthio]-1-méthyléthylthio)phénoxy])
- Keyword (en)
- Animal Antiinflammatory agent Antioxidant Chronic Benzenic compound Cytokine Dithioacetal In vitro In vivo Inhibitor Lipophilicity Inflammatory disease Phenols Physicochemical properties Cell adhesion molecule Vascular cell adhesion molecule 1 Dose activity relation Structure activity relation Chemical synthesis Triol
- Keyword (es)
- Animal Antiinflamatorio Antioxidante Crónico Compuesto bencénico Citoquina Ditioacetal In vitro In vivo Inhibidor Lipofilia Enfermedad inflamatoria Fenoles Propiedad fisicoquímica Proteína CAM Proteína VCAM1 Relación dosis respuesta Relación estructura actividad Síntesis química Triol
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16305179
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049685u 
https://dx.doi.org/10.1021/jm049685u
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