Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity
- Author
- PALUCHOWSKA, Maria H1 ; BUGNO, Ryszard1 ; BOJARSKI, Andrzej J1 ; CHARAKCHIEVA-MINOL, Sijka1 ; DUSZYNSKA, Beata1 ; TATARCZYNSKA, Ewa2 ; KŁODZINSKA, Aleksandra2 ; STACHOWICZ, Katarzyna2 ; CHOJNACKA-WOJCIK, Ewa2
[1] Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Science, 12 Smętna Street, 31-343 Kraków, Poland
[2] Department of New Drugs Research, Institute of Pharmacology Polish Academy of Science, 12 Smętna Street, 31-343 Kraków, Poland - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 4, pp 1195-1200, 6 p ; ref : 20 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Agoniste partiel Agoniste Animal Benzène dérivé Composé monocyclique Cycle 6 chaînons Cyclohexane dérivé Flexibilité moléculaire Gépirone Hétérocycle azote Imide In vitro In vivo Pipérazine dérivé Rat Relation structure activité Rigidité moléculaire Récepteur dopaminergique D2 Récepteur sérotoninergique 5-HT1A Récepteur sérotoninergique 5-HT2A Souris Synthèse chimique Sélectivité Pipéridine-2,6-dione(1-[4-(4-arylpipérazino)butyl]-4,4-diméthyl) Pipéridine-2,6-dione(1-[4-(4-arylpipérazino)cyclohexyl]-4,4-diméthyl) Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Partial agonist Agonist Animal Benzene derivatives Monocyclic compound Six membered ring Cyclohexane derivatives Molecular flexibility Gepirone Nitrogen heterocycle Imide In vitro In vivo Piperazine derivatives Rat Structure activity relation Molecular rigidity D2 Dopamine receptor 5-HT1A Serotonine receptor 5-HT2A serotonin receptor Mouse Chemical synthesis Selectivity Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Agonista parcial Agonista Animal Benceno derivado Compuesto monocíclico Ciclo 6 eslabones Ciclohexano derivado Flexibilidad molecular Gepirona Heterociclo nitrógeno Imida In vitro In vivo Piperazina derivado Rata Relación estructura actividad Rigidez molecular Receptor dopaminérgico D2 Receptor serotoninérgico 5-HT1A Receptor serotoninérgico 5-HT2A Ratón Síntesis química Selectividad Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09C Serotoninergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16455676
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.11.019 
https://dx.doi.org/10.1016/j.bmc.2004.11.019
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