New potential antihistaminic compounds. virtual combinatorial chemistry, computational screening, real synthesis, and pharmacological evaluation
- Auteur
- DUART, Maria J1 ; ANTON-FOS, Gerardo M2 ; ALEMAN, Pedro A2 ; GAY-ROIG, Joan B2 ; GONZALEZ-ROSENDE, Maria E2 ; GALVEZ, Jorge3 ; GARCIA-DOMENECH, Ramon3
[1] Departamento de Química, Bioquímica y Biología Molecular, Universidad Cardenal Herrera-CEU, Valencia, Spain
[2] Departamento de Ingenieria, División Farmacia y Tecnología Farmacéutica, Universidad Miguel Hernández, Alicante, Spain
[3] Unidad de Diseño de Fármacos y Conectividad Molecular, Departamento de Química Física, Facultad de Farmacia, Universitat de Valencia, Valencia, Spain - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 4, pp 1260-1264, 5 p ; ref : 19 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Domaine scientifique
- Pharmacology drugs
- Editeur
- American Chemical Society, Washington, DC
- Pays de publication
- United States
- Type de document
- Article
- Langue
- English
- Mot clé (fr)
- Amine Antihistaminique Chimie combinatoire Chimiothèque Composé aromatique Composé bicyclique Composé tricyclique Cycle 6 chaînons Hétérocycle azote In vitro Modèle mathématique Modélisation Pipérazine dérivé Prédiction Relation structure activité Synthèse chimique Urées Criblage virtuel Dibenzo[a,d]cycloheptène dérivé Dibenzo[b,f]azépine-5-carboxamide dérivé dérivé Dibenzoazépine Dibenzocycloheptène Isoquinoléine-2-carboxamide dérivé Pipéridine-1-carboxamide dérivé
- Mot clé (en)
- Amine Antihistaminic Combinatorial chemistry Chemical compound library Aromatic compound Bicyclic compound Tricyclic compound Six membered ring Nitrogen heterocycle In vitro Mathematical model Modeling Piperazine derivatives Prediction Structure activity relation Chemical synthesis Ureas Virtual screening
- Mot clé (es)
- Amina Antihistamínico Química combinatoria Quimioteca Compuesto aromático Compuesto bicíclico Compuesto tricíclico Ciclo 6 eslabones Heterociclo nitrógeno In vitro Modelo matemático Modelización Piperazina derivado Predicción Relación estructura actividad Síntesis química Ureas
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02J Histamine et antagonistes. Allergie
- Discipline
- Pharmacological treatments
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 16542733
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm040877z 
https://dx.doi.org/10.1021/jm040877z
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