Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
- Author
- GLASSON, Sonya S1 ; ASKEW, Roger2 ; MAJUMDAR, Manas K1 ; MORRIS, Elisabeth A1 ; SHEPPARD, Barbara3 ; CARITO, Brenda3 ; BLANCHET, Tracey1 ; MA, Hak-Ung1 ; FLANNWY, Carl R1 ; PELOSO, Dlane1 ; KANKL, Kim2 ; ZHIYONG YANG1
[1] Department of Women's Health and Bone, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, United States
[2] Department of Genomics, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, United States
[3] Department of Drug Safety and Metabolism, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, United States - Source
Nature (London). 2005, Vol 434, Num 7033, pp 644-648, 5 p ; ref : 16 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Arthrose Cartilage Dégradation Délétion Matrice extracellulaire Modèle animal Peptidases Protéoglycane Souris Gène Adamts5 Arthropathie Enzyme Hydrolases Maladie dégénérative Mammalia Rodentia Système ostéoarticulaire pathologie Système ostéoarticulaire Vertebrata
- Keyword (en)
- Osteoarthritis Cartilage Degradation Deletion Extracellular matrix Animal model Peptidases Proteoglycan Mouse Arthropathy Enzyme Hydrolases Degenerative disease Mammalia Rodentia Diseases of the osteoarticular system Osteoarticular system Vertebrata
- Keyword (es)
- Artrosis Cartílago Degradación Deleción Matriz extracelular Modelo animal Peptidases Proteoglicano Ratón Artropatía Enzima Hydrolases Enfermedad degenerativa Mammalia Rodentia Sistema osteoarticular patología Sistema osteoarticular Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15E Osteoarthritis
- Discipline
- Osteoarticular pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16648115
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature03369 
https://dx.doi.org/10.1038/nature03369
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