The irinotecan/5-fluorouracil combination induces apoptosis and enhances manganese superoxide dismutase activity in HT-29 human colon carcinoma cells

Author

GRIVICICH, Ivana^{1 2 3} ; REGNER, Andréa^{2 4} ; DA ROCHA, Adriana B^{2 4} ; KAYSER, Guilherme B² ; SCHUNEMANN, Daniel P^{2 4} ; GRASS, Luciano B² ; ALVES, Pedro A. G² ; HENRIQUES, Joao A. P^{3 5 6} ; SCHWARTSMANN, Gilberto^{1 3}
[1] South-American Office of Anticancer Drug Development, Porto Alegre, Brazil
[2] Laboratório de Marcadores de Estresse Celular, Centro de Pesquisas em Ciências Médicas, Universidade Luterana do Brasil, Canoas, Brazil
[3] Programa de Pós Graduaçâo em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
[4] Programa de Pós Graduaçâo em Diagnóstico Genético e Molecular, Universidade Luterana do Brasil, Canoas, Brazil
[5] Departmento de Biofísica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
[6] Faculdade de Farmàcia, Universidade Luterana do Brasil, Canoas, Brazil

Source

Chemotherapy (Basel). 2005, Vol 51, Num 2-3, pp 93-102, 10 p ; ref : 67 ref

CODEN

CHTHBK

ISSN

0009-3157

Scientific domain

Pharmacology drugs

Publisher

Karger, Basel

Publication country

Switzerland

Document type

Article

Language

English

Author keyword

Apoptosis CPT-11/5-FU combination HT-29 human colon carcinoma cells Mn-SOD activity

Keyword (fr)

Activité enzymatique Apoptose Cellule tumorale Fluorouracil Homme In vitro Irinotécan Mort cellulaire Superoxide dismutase Camptothécine dérivé Carcinome côlon Pyrano indolizino quinoléine dérivé Anticancéreux Antimétabolite Appareil digestif pathologie Côlon pathologie DNA topoisomerase Enzyme Fluoropyrimidine dérivé Inhibiteur enzyme Intestin pathologie Isomerases Methyltransferases Oxidoreductases Pyrimidine dérivé Thymidylate synthase Transferases Tumeur maligne

Keyword (en)

Enzymatic activity Apoptosis Tumor cell Fluorouracil Human In vitro Irinotecan Cell death Superoxide dismutase Colon carcinoma Antineoplastic agent Antimetabolic Digestive diseases Colonic disease DNA topoisomerase Enzyme Fluoropyrimidine derivatives Enzyme inhibitor Intestinal disease Isomerases Methyltransferases Oxidoreductases Pyrimidine derivatives Thymidylate synthase Transferases Malignant tumor

Keyword (es)

Actividad enzimática Apoptosis Célula tumoral Fluorouracilo Hombre In vitro Irinotecán Muerte celular Superoxide dismutase Carcinoma colón Anticanceroso Antimetabólito Aparato digestivo patología Colón patología DNA topoisomerase Enzima Fluoropirimidina derivado Inhibidor enzima Intestino patología Isomerases Methyltransferases Oxidoreductases Pirimidina derivado Thymidylate synthase Transferases Tumor maligno

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B01 Tumors

Discipline

Gastroenterology. Liver. Pancreas. Abdomen Pharmacological treatments

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

16837521

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS