Nonpeptidic urotensin-II receptor antagonists I : in vitro pharmacological characterization of SB-706375
- Author
- DOUGLAS, Stephen A1 ; BEHM, David J1 ; BUCKLEY, Peter T3 ; SCHMIDT, Dulcie B3 ; WIXTED, William E3 ; WIDDOWSON, Katherine4 ; RILEY, Graham5 ; JIAN JIN6 ; GALLAGHER, Timothy F7 ; SCHMIDT, Stanley J7 ; RIDGERS, Lance7 ; CHRISTMANN, Lisa T7 ; AIYAR, Nambi V1 ; KEENAN, Richard M7 ; KNIGHT, Steven D7 ; DHANAK, Dashyant7 ; NASELSKY, Diane1 ; DISA, Jyoti1 ; BROOKS, David P1 ; OHLSTEIN, Eliot H1 ; GLEASON, John G2 ; SARAU, Henry M3 ; FOLEY, James J3
[1] CVU Department of Biology, Cardiovascular and Urogenital and Respiratory and Inflammation Centers of Excellence for Drug Discovery, GlaxoSmithKline, 709 Swedeland Road, UW2510 King of Prussia, PA 19406-0939, United States
[2] CVU Department of Medicinal Chemistry, Cardiovascular and Urogenital and Respiratory and Inflammation Centers of Excellence for Drug Discovery, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406-0939, United States
[3] RIRP Department of Biology, Cardiovascular and Urogenital and Respiratory and Inflammation Centers of Excellence for Drug Discovery, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406-0939, United States
[4] RIRP Department of Medicinal Chemistry, Cardiovascular and Urogenital and Respiratory and Inflammation Centers of Excellence for Drug Discovery, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406-0939, United States
[5] Assay Development and Compound Profiling, Discovery Research, GlaxoSmithKline, New Frontiers Park (North), Third Avenue, Harlow, Essex CM19 5AW, United States
[6] High Throughput Chemistry, Discovery Research, GlaxoSmithKline, Collegeville, PA 19426, United States
[7] Medicinal Chemistry, Microbial, Musculoskeletal and Proliferative Diseases Center of Excellence for Drug Discovery, GlaxoSmithKline, Collegeville, PA 19426, United States - Source
British journal of pharmacology. 2005, Vol 145, Num 5, pp 620-635, 16 p ; ref : 1 p.3/4
- CODEN
- BJPCBM
- ISSN
- 0007-1188
- Scientific domain
- Pharmacology drugs
- Publisher
- Nature Publishing, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- G-protein-coupled receptor GPR-14 SB-657510 SB-706375 UT receptor Urotensin heart failure hypertension radioligand binding vasoconstriction
- Keyword (fr)
- Antagoniste Caractérisation Composé non peptide Hypertension artérielle In vitro Insuffisance cardiaque Protéine G Récepteur biologique Urotensine Vasoconstriction Récepteur urotensine II Appareil circulatoire pathologie Cardiopathie Hormone hypothalamique Vasomotricité
- Keyword (en)
- Antagonist Characterization Non peptide compound Hypertension In vitro Heart failure G protein Biological receptor Urotensin Vasoconstriction Urotensin II receptor Cardiovascular disease Heart disease Hypothalamic hormone Vasomotricity
- Keyword (es)
- Antagonista Caracterización Compuesto no péptido Hipertensión arterial In vitro Insuficiencia cardíaca Proteína G Receptor biológico Urotensina Vasoconstricción Aparato circulatorio patología Cardiopatía Hormona hipotalámica Vasomotricidad
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16933073
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.bjp.0706229 
https://dx.doi.org/10.1038/sj.bjp.0706229
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