Discorhabdin P, a new enzyme inhibitor from a deep-water caribbean sponge of the genus Batzella
- Author
- GUNASEKERA, S. P1 ; MCCARTHY, P. J1 ; LONGLEY, R. E1 ; POMPONI, S. A1 ; WRIGHT, A. E1 ; LOBKOVSKY, E2 ; CLARDY, J2
[1] Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, Florida 34946, United States
[2] Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, United States - Source
Journal of natural products (Print). 1999, Vol 62, Num 1, pp 173-175
- CODEN
- JNPRDF
- ISSN
- 0163-3864
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
/
American Society of Pharmacognosy, Glendale, AZ
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Analyse structurale Animal Anticancéreux Cellule tumorale Composé pentacyclique Cysteine endopeptidases Cytotoxicité Diénone Eau profonde Homme Hétérocycle azote In vitro Inhibiteur enzyme Isolement Leucémie P388 Lignée cellulaire Milieu marin Origine animale Pharmacognosie Phosphoprotein phosphatase Porifera Poumon Souris Spirane Batzella Discorhabdine P Lignée A549 Spiro[cyclohexane-1,10p-pyrrolo[4,3,2-de][1,7]phénanthroline-4,6p-dione] dérivé Mer des Caraïbes Brome Composé organique Enzyme Esterases Hydrolases Invertebrata Mammalia Peptidases Phosphoric monoester hydrolases Rodentia Vertebrata
- Keyword (en)
- Biological activity Structural analysis Animal Antineoplastic agent Tumor cell Pentacyclic compound Cysteine endopeptidases Cytotoxicity Dienone Deep water Human Nitrogen heterocycle In vitro Enzyme inhibitor Isolation P388-Leukemia Cell line Marine environment Animal origin Pharmacognosy Phosphoprotein phosphatase Porifera Lung Mouse Spiran Caribbean Sea Bromine Organic compounds Enzyme Esterases Hydrolases Invertebrata Mammalia Peptidases Phosphoric monoester hydrolases Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Análisis estructural Animal Anticanceroso Célula tumoral Compuesto pentacíclico Cysteine endopeptidases Citotoxicidad Dienona Agua profunda Hombre Heterociclo nitrógeno In vitro Inhibidor enzima Aislamiento Leucemia P388 Línea celular Medio marino Origen animal Farmacognosia Phosphoprotein phosphatase Porifera Pulmón Ratón Espirano Mar del Caribe Bromo Compuesto orgánico Enzima Esterases Hydrolases Invertebrata Mammalia Peptidases Phosphoric monoester hydrolases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A04 Pharmacognosy. Homeopathy. Health food
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 1693372
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/np980293y 
https://dx.doi.org/10.1021/np980293y
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