Molecular modeling, synthesis, and preliminary biological evaluation of glutathione-S-transferase inhibitors as potential therapeutic agents
- Author
- PROCOPIO, Antonio1 ; ALCARO, Stefano1 ; CUNDARI, Sante2 ; DE NINO, Antonio2 ; ORTUSO, Francesco1 ; SACCHETTA, Paolo3 ; PENNELLI, Alfonso3 ; SINDONA, Giovanni2
Dipartimento di Chimica, Università della Calabria, Ponte Bucci, cubo 12C, 87036 Arcavacata di Rende (Cs), Italy
[1] Dipartimento di Scienze Farmaco-Biologiche, Università della Magna Graecia, Complesso Nini Barbieri, 88021 Roccelletta di Borgia (Cz), Italy
[2] R&D Department, Sigma Tau i.f.r. SpA, via Pontina km 30.400, 00040 Pomezia (Rome), Italy
[3] Dipartimento di Scienze Biomediche, Università G. d'Annunzio Chieti Via dei Vestini, 65100 Chieti, Italy - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 19, pp 6084-6089, 6 p ; ref : 33 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Agent alkylant Anticancéreux Glutathione transferase In vitro Inhibiteur enzyme Isozyme Modèle moléculaire Modélisation Peptide soufre Peptide Résistance Synthèse chimique Tripeptide Cystéine dérivé Glutamique acide dérivé Glycine(γ-glutamyl-[S-(2-hydroxy-1-phényléthyl)cystéinyl]) Inhibiteur glutathione transferase Enzyme Transferases
- Keyword (en)
- Biological activity Alkylating agent Antineoplastic agent Glutathione transferase In vitro Enzyme inhibitor Isozyme Molecular model Modeling Sulfur peptide Peptides Resistance Chemical synthesis Tripeptide Enzyme Transferases
- Keyword (es)
- Actividad biológica Agente alquilante Anticanceroso Glutathione transferase In vitro Inhibidor enzima Isozima Modelo molecular Modelización Péptido azufre Péptido Resistencia Síntesis química Tripéptido Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17113319
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0504609 
https://dx.doi.org/10.1021/jm0504609
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