Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

Author

BURCHERT, A¹ ; WANG, Y¹ ; CAI, D¹ ; VON BUBNOFF, N² ; PASCHKA, P³ ; MÜLLER-BRÜSSELBACH, S⁴ ; OTTMANN, O. G⁵ ; DUYSTER, J² ; HOCHHAUS, A³ ; NEUBAUER, A¹
[1] Klinikum der Philipps Universität Marburg, Klinik für Hämatologie, Onkologie und Immunologie, Marburg, Germany
[2] Department of Internal Medicine III, Technical University of Munich, Munich, Germany
[3] Fakultät für Klinische Medizin Mannheim der Universitaet Heidelberg, III, Medizinische Klinik, Mannheim, Germany
[4] Department of Medicine, Institute of Molecular Biology and Tumor Research, Philipps University, Marburg, Germany
[5] University Hospital Frankfurt, Medizinische Klinik III, Frankfurt, Germany

Source

Leukemia. 2005, Vol 19, Num 10, pp 1774-1782, 9 p ; ref : 51 ref

CODEN

LEUKED

ISSN

0887-6924

Scientific domain

Medical oncology; Hematology

Publisher

Nature Publishing, London

Publication country

United Kingdom

Document type

Article

Language

English

Author keyword

Akt signaling BCR/ABL CML PI3-kinase imatinib resistance mTOR inhibitor

Keyword (fr)

1-Phosphatidylinositol 3-kinase Akt protein kinase Anticancéreux Chromosome C9 anormal Chromosome G22 anormal Chromosome Ph1 Chronique Gène hybride Hématologie Imatinib Inhibiteur enzyme Leucémie myéloïde Protein kinase Protein-tyrosine kinase Régulation Résistance Translocation chromosomique Gène abl Gène bcr Inhibiteur tyrosine kinase Protein kinase mTOR Protéine bcr-abl Voie de signalisation Aberration chromosomique Chromosome anormal Enzyme Hémopathie maligne Myéloprolifératif syndrome Transferases

Keyword (en)

1-Phosphatidylinositol 3-kinase Akt protein kinase Antineoplastic agent Abnormal chromosome C9 Abnormal chromosome G22 Philadelphia chromosome Chronic Hybrid gene Hematology Imatinib Enzyme inhibitor Chronic myelocytic leukemia Protein kinase Protein-tyrosine kinase Regulation(control) Resistance Chromosome translocation Protein kinase mTOR Bcr-abl protein Signaling pathway Chromosomal aberration Abnormal chromosome Enzyme Malignant hemopathy Myeloproliferative syndrome Transferases

Keyword (es)

1-Phosphatidylinositol 3-kinase Akt protein kinase Anticanceroso Cromosoma C9 anormal Cromosoma G22 anormal Cromosoma Ph1 Crónico Gen híbrido Hematología Imatinib Inhibidor enzima Leucemia mieloidea Protein kinase Protein-tyrosine kinase Regulación Resistencia Translocación cromosómica Aberración cromosómica Cromosoma anormal Enzima Hemopatía maligna Mieloproliferativo síndrome Transferases

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B23 Medical genetics / 002B23B Chromosome aberrations

Discipline

Blood diseases Medical genetics

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

17136879

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS