The structural basis for kainoid selectivity at AMPA receptors revealed by low-mode docking calculations
- Author
- CARCACHE, Luis M1 ; RODRIGUEZ, Jonierr1 ; REIN, Kathleen S1
[1] Department of Chemistry, Florida International University, 11200 SW 8th St, Miami, FL 33199, United States - Source
Bioorganic & medicinal chemistry. 2003, Vol 11, Num 4, pp 551-559, 9 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide kaïnique Affinité Agoniste partiel Agoniste Composé aliphatique Composé diénique conjugué Conformation Cycle 5 chaînons Energie liaison Fixation biologique Fixation ligand Hétérocycle azote Liaison hydrogène Modèle 3 dimensions Modèle moléculaire Modélisation Propriété thermodynamique Prédiction Relation structure activité Récepteur AMPA Récepteur glutamate Récepteur ionotropique Récepteur kaïnate Structure cristalline Stéréoisomère Stéréosélectivité Sélectivité Acromélique acide Domoïque acide Hepta-3,5-diénoïque acide dérivé Isodomoïque acide Pyridin-2-one dérivé Pyridine-2-carboxylique acide dérivé Pyrrolidine-3-acétique acide dérivé
- Keyword (en)
- Kainic acid Affinity Partial agonist Agonist Aliphatic compound Conjugated dienic compound Conformation Five membered ring Binding energy Biological fixation Ligand binding Nitrogen heterocycle Hydrogen bond Three dimensional model Molecular model Modeling Thermodynamic properties Prediction Structure activity relation AMPA receptor Glutamate receptor Ionotropic receptor Kainate receptor Crystalline structure Stereoisomer Stereoselectivity Selectivity
- Keyword (es)
- Acido kaínico Afinidad Agonista parcial Agonista Compuesto alifático Compuesto diénico conjugado Conformación Ciclo 5 eslabones Energía enlace Fijación biológica Fijación ligando Heterociclo nitrógeno Enlace hidrógeno Modelo 3 dimensiones Modelo molecular Modelización Propiedad termodinámica Predicción Relación estructura actividad Receptor AMPA Receptor glutámato Receptor ionotropico Receptor kainato Estructura cristalina Estereoisómero Estereoselectividad Selectividad
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09E Glutamatergic system (aspartate and other excitatory aminoacids)
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17280505
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0968-0896(02)00448-0 
https://dx.doi.org/10.1016/S0968-0896(02)00448-0
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