NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia
- Author
- KIMURA, Shinya; NAITO, Haruna; NAKAYA, Yohei; NARUOKA, Haruna; WAKAYAMA, Tatsushi; NASU, Kimio; ASAKI, Tetsuo; NIWA, Tomoko; HIRABAYASHI, Kazuko; MAEKAWA, Taira; SEGAWA, Hidekazu; KURODA, Junya; YUASA, Takeshi; SATO, Kiyoshi; YOKOTA, Asumi; KAMITSUJI, Yuri; KAWATA, Eri; ASHIHARA, Eishi
Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan
Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto, Japan - Source
Blood. 2005, Vol 106, Num 12, pp 3948-3954, 7 p ; ref : 41 ref
- ISSN
- 0006-4971
- Scientific domain
- Medical oncology; Hematology
- Publisher
- The Americain Society of Hematology, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Animal Anticancéreux Chromosome Ph1 Gène hybride Imatinib Inhibiteur enzyme Protein kinase Protein-tyrosine kinase Protéine fusion Résistance traitement Souris Gène abl Gène bcr Inhibiteur tyrosine kinase Leucémie Philadelphie positive NS-187 Protein kinase Lyn Protéine bcr-abl Aberration chromosomique Chromosome anormal Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Biological activity Animal Antineoplastic agent Philadelphia chromosome Hybrid gene Imatinib Enzyme inhibitor Protein kinase Protein-tyrosine kinase Fusion protein Treatment resistance Mouse Tyrosine kinase inhibitor Philadelphia-positive leukemia Bcr-abl protein Chromosomal aberration Abnormal chromosome Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Actividad biológica Animal Anticanceroso Cromosoma Ph1 Gen híbrido Imatinib Inhibidor enzima Protein kinase Protein-tyrosine kinase Proteína fusionada Resistencia tratamiento Ratón Aberración cromosómica Cromosoma anormal Enzima Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B23 Medical genetics / 002B23B Chromosome aberrations
- Discipline
- Medical genetics
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17314383
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1182/blood-2005-06-2209 
https://dx.doi.org/10.1182/blood-2005-06-2209
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