BRAF mutation predicts sensitivity to MEK inhibition
- Author
- SOLIT, David B1 2 ; GARRAWAY, Levi A3 4 ; GOLUB, Todd R4 7 ; SEBOLT-LEOPOLD, Judith8 ; SELLERS, William R3 4 ; ROSEN, Neal1 2 ; PRATILAS, Christine A2 5 ; SAWAI, Ayana2 ; GETZ, Gad4 ; BASSO, Andrea2 ; QING YE2 ; LOBO, Jose M2 ; YUHONG SHE2 ; OSMAN, Iman6
[1] Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, United States
[2] Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, United States
[3] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, United States
[4] Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, United States
[5] Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, United States
[6] Departments of Medicine and Urology, New York University Medical Center, 550 First Avenue, New York, New York 10016, United States
[7] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, United States
[8] Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105, United States - Source
Nature (London). 2006, Vol 439, Num 7074, pp 358-362, 5 p ; ref : 28 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Anticancéreux Cancérologie Chimiothérapie Gène onc cellulaire Homme Inhibiteur enzyme Lignée cellulaire établie Mutation Protooncogène Sensibilité Souris Traitement Tumeur maligne Gène BRAF Lignée NCI60 Mitogen-activated protein kinase kinase Génétique Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Antineoplastic agent Cancerology Chemotherapy C-Onc gene Human Enzyme inhibitor Established cell line Mutation Protooncogene Sensitivity Mouse Treatment Malignant tumor BRAF Gene Genetics Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Anticanceroso Cancerología Quimioterapia Gen onc celular Hombre Inhibidor enzima Línea celular establecida Mutación Protooncogen Sensibilidad Ratón Tratamiento Tumor maligno Gen BRAF Genética Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04D Animal tumors. Experimental tumors / 002B04D02 Experimental tumors, general aspects
- Discipline
- Pharmacological treatments Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17391907
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature04304 
https://dx.doi.org/10.1038/nature04304
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