Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
- Auteur
- OTA, H1 2 ; TOKUNAGA, E1 3 ; CHANG, K1 ; HIKASA, M1 ; LIJIMA, K2 ; ETO, M2 ; KOZAKI, K2 ; AKISHITA, M2 ; OUCHI, Y2 ; KANEKI, M1 3
[1] Deportment of Anesthesia & Critical Care, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States
[2] Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan
[3] Shriners Hospital for Children, Boston, MA, United States - Source
Oncogene (Basingstoke). 2006, Vol 25, Num 2, pp 176-185, 10 p ; ref : 67 ref
- ISSN
- 0950-9232
- Domaine scientifique
- Cell biology, histology; Medical oncology; Genetics
- Editeur
- Nature Publishing, Basingstoke
- Pays de publication
- United Kingdom
- Type de document
- Article
- Langue
- English
- Mot clé auteur
- Akt/PKB MAPK Ras Sirti Sirtinol cellular senescence
- Mot clé (fr)
- Akt protein kinase Carcinogenèse Croissance Homme Inhibiteur Mitogen-activated protein kinase Sénescence Tumeur maligne Enzyme
- Mot clé (en)
- Akt protein kinase Carcinogenesis Growth Human Inhibitor Mitogen-activated protein kinase Senescence Malignant tumor Enzyme
- Mot clé (es)
- Akt protein kinase Carcinogénesis Crecimiento Hombre Inhibidor Mitogen-activated protein kinase Senescencia Tumor maligno Enzima
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002A Sciences biologiques fondamentales et appliquees. Psychologie / 002A04 Biologie moleculaire et cellulaire / 002A04H Physiologie cellulaire / 002A04H04 Transformation cellulaire et carcinogenèse. Action des oncogènes et antioncogènes
- Discipline
- Molecular and cell biology
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 17642925
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.onc.1209049 
https://dx.doi.org/10.1038/sj.onc.1209049
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