Designed divergent evolution of enzyme function

Author

YOSHIKUNI, Yasuo^{1 2} ; FERRIN, Thomas E^{1 3} ; KEASLING, Jay D^{1 2 4 5}
[1] UCSF/UCB Joint Graduate Group in Bioengineering, University of California at Berkeley, Berkeley, California 94720, United States
[2] Synthetic Biology Department, Physical Bioscience Division, Lawrence Berkeley National Laboratory, Berkeley, California 94710, United States
[3] Department of Pharmaceutical Chemistry and Biopharmaceutical Sciences, University of California at San Francisco, San Francisco, California 94143, United States
[4] Department of Chemical Engineering, University of California at Berkeley, Berkeley, California 94720, United States
[5] California Institute for Quantitative Biomedical Research (QB3), University of California at Berkeley, Berkeley, California 94720, United States

Source

Nature (London). 2006, Vol 440, Num 7087, pp 1078-1082, 5 p ; ref : 30 ref

CODEN

NATUAS

ISSN

0028-0836

Scientific domain

Multidisciplinary

Publisher

Nature Publishing, London

Publication country

United Kingdom

Document type

Article

Language

English

Keyword (fr)

Conception Enzyme Evolution moléculaire dirigée Modèle mathématique Site actif Site fixation Substitution

Keyword (en)

Design Enzyme Directed molecular evolution Mathematical model Active site Binding site Substitution

Keyword (es)

Diseño Enzima Evolución molecular dirigida Modelo matemático Lugar activo Sitio fijación Substitución

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology / 002A31C Methods. Procedures. Technologies / 002A31C04 Protein engineering

Discipline

Biotechnology

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

17700494

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS