A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
- Author
- FESKE, Stefan1 2 ; GWACK, Yousang1 3 ; PRAKRIYA, Murali4 ; SRIKANTH, Sonal1 3 ; PUPPEL, Sven-Holger1 ; TANASA, Bogdan1 ; HOGAN, Patrick G1 ; LEWIS, Richard S5 ; DALY, Mark6 7 ; RAO, Anjana1 3
[1] The CBR Institute for Biomedical Resoarch, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, United States
[2] Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, United States
[3] Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, United States
[4] Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Felnberg School of Medicine, Chicago, Illinois 60611, United States
[5] Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, United States
[6] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, United States
[7] Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States - Source
Nature (London). 2006, Vol 441, Num 7090, pp 179-185, 7 p ; ref : 47 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Calcium ion Canal ionique Immunodéficit combiné sévère Mutation Régulateur Réponse immune Protéine Orai1 Immunopathologie
- Keyword (en)
- Calcium ion Ionic channel Severe combined immunodeficiency Mutation Regulator Immune response Immunopathology
- Keyword (es)
- Calcio ión Canal iónico Inmunodeficiencia combinada grave Mutación Regulador Respuesta inmune Inmunopatología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B06 Immunopathology / 002B06D Immunodeficiencies. Immunoglobulinopathies / 002B06D01 Immunodeficiencies
- Discipline
- Immunopathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 17741470
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature04702 
https://dx.doi.org/10.1038/nature04702
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