Probing the role of the covalent linkage of ferrocene into a chloroquine template
- Author
- BIOT, Christophe1 ; DAHER, Wassim2 ; BROCARD, Jacques1 ; KHALIFE, Jamal2 ; FORFAR-BARES, Isabelle6 ; DIVE, Daniel2 ; NDIAYE, Cheikh M1 ; MELNYK, Patricia3 ; PRADINES, Bruno4 ; CHAVAIN, Natascha1 ; PELLET, Alain5 ; FRAISSE, Laurent5 ; PELINSKI, Lydie1 ; JARRY, Christian6
[1] Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108, 59652, Villeneuve d'Ascq, France
[2] Inserm, U547, Institut Pasteur, 1 rue du Pr Calmette, B.P. 245, 59019 Lille, France
[3] UMR CNRS 8161, Universités Lillel et Lille2, IPL, 1 rue du Pr. Calmette, B.P. 245, 59019 Lille, France
[4] Institut de Médecine Tropicale du Service de Santé des Armées, Unité de Parasitologie, Bd Charles Livon, Parc le Pharo, BP 46, 13998 Marseille Armées, France
[5] Sanofi-Aventis Recherche, Discovery Department, 31000 Toulouse, France
[6] EA 2962 Pharmacochimie Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, France - Source
Journal of medicinal chemistry (Print). 2006, Vol 49, Num 15, pp 4707-4714, 8 p ; ref : 22 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antipaludique Antiparasitaire Antiprotozoaire Chloroquine Fer Composé organique In vitro Liaison covalente Lipophilie Mécanisme action Métallocène Pigment Plasmodium falciparum Propriété physicochimique Quinoléine dérivé Relation structure activité Relation structure propriété Synthèse chimique Ferrocène dérivé Ferrocène(1-[7-chloro-4-quinolylaminométhyl]-2-[(dialkylamino)méthyl]) Ferroquine Hémozoine Apicomplexa Protozoa
- Keyword (en)
- Antimalarial Parasiticide Antiprotozoal agent Chloroquine Iron Organic compounds In vitro Covalent bond Lipophilicity Mechanism of action Metallocene Pigments Plasmodium falciparum Physicochemical properties Quinoline derivatives Structure activity relation Property structure relationship Chemical synthesis Apicomplexa Protozoa
- Keyword (es)
- Antipalúdico Antiparasitario Antiprotozoario Cloroquina Hierro Compuesto orgánico In vitro Enlace covalente Lipofilia Mecanismo acción Metaloceno Pigmento Plasmodium falciparum Propiedad fisicoquímica Quinolina derivado Relación estructura actividad Relación estructura propiedad Síntesis química Apicomplexa Protozoa
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18001562
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm060259d 
https://dx.doi.org/10.1021/jm060259d
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