Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
- Author
- ÖZCAN, Umut1 ; YILMAZ, Erkan1 ; ÖZCAN, Lale1 ; FURUHASHI, Masato1 ; VAILLANCOURT, Eric1 ; SMITH, Ross O1 ; GÖRGÜN, Cem Z1 ; HOTAMISLIGIL, Gökhan S1
[1] Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, United States - Source
Science (Washington, D.C.). 2006, Vol 313, Num 5790, pp 1137-1140, 4 p
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide ursodéoxycholique Animal Diabète Etat nutritionnel Foie Glucose Homéostasie Hyperglycémie Insuline Modèle animal Obésité Réticulum endoplasmique Sensibilité Souris Stress Taurine Traitement Appareil digestif Endocrinopathie Hormone pancréatique Mammalia Rodentia Trouble nutrition Vertebrata
- Keyword (en)
- Ursodeoxycholic acid Animal Diabetes mellitus Nutritional status Liver Glucose Homeostasis Hyperglycemia Insulin Animal model Obesity Endoplasmic reticulum Sensitivity Mouse Stress Taurine Treatment Digestive system Endocrinopathy Pancreatic hormone Mammalia Rodentia Nutrition disorder Vertebrata
- Keyword (es)
- Acido ursodeoxicólico Animal Diabetes Estado nutricional Hígado Glucosa Homeostasis Hiperglicemia Insulina Modelo animal Obesidad Retículo endoplásmico Sensibilidad Ratón Estrés Taurina Tratamiento Aparato digestivo Endocrinopatía Hormona pancreática Mammalia Rodentia Trastorno nutricíon Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance / 002B21E01A Etiopathogenesis. Screening. Investigations. Target tissue resistance
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B22 Metabolic diseases / 002B22B Obesity
- Discipline
- Endocrinopathies Metabolic diseases
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18078692
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1126/science.1128294 
https://dx.doi.org/10.1126/science.1128294
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1128294\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:104:\"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes\";s:9:\"\u0000*\u0000jtitle\";s:26:\"Science (Washington, D.C.)\";s:9:\"\u0000*\u0000stitle\";s:20:\"Science (Wash. D.C.)\";s:7:\"\u0000*\u0000date\";s:4:\"2006\";s:9:\"\u0000*\u0000volume\";s:3:\"313\";s:8:\"\u0000*\u0000issue\";s:4:\"5790\";s:8:\"\u0000*\u0000spage\";s:4:\"1137\";s:8:\"\u0000*\u0000epage\";s:4:\"1140\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0036-8075\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"\u00d6ZCAN\";s:10:\"\u0000*\u0000aufirst\";s:4:\"Umut\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:13:\"YILMAZ, Erkan\";i:1;s:12:\"\u00d6ZCAN, Lale\";i:2;s:17:\"FURUHASHI, Masato\";i:3;s:18:\"VAILLANCOURT, Eric\";i:4;s:13:\"SMITH, Ross O\";i:5;s:15:\"G\u00d6RG\u00dcN, Cem Z\";i:6;s:23:\"HOTAMISLIGIL, G\u00f6khan S\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"SCIEAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:104:\"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:51:\"American Association for the Advancement of Science\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"4\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1128294\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:104:\"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes\";s:9:\"\u0000*\u0000jtitle\";s:26:\"Science (Washington, D.C.)\";s:9:\"\u0000*\u0000stitle\";s:20:\"Science (Wash. D.C.)\";s:7:\"\u0000*\u0000date\";s:4:\"2006\";s:9:\"\u0000*\u0000volume\";s:3:\"313\";s:8:\"\u0000*\u0000issue\";s:4:\"5790\";s:8:\"\u0000*\u0000spage\";s:4:\"1137\";s:8:\"\u0000*\u0000epage\";s:4:\"1140\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0036-8075\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"\u00d6ZCAN\";s:10:\"\u0000*\u0000aufirst\";s:4:\"Umut\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:13:\"YILMAZ, Erkan\";i:1;s:12:\"\u00d6ZCAN, Lale\";i:2;s:17:\"FURUHASHI, Masato\";i:3;s:18:\"VAILLANCOURT, Eric\";i:4;s:13:\"SMITH, Ross O\";i:5;s:15:\"G\u00d6RG\u00dcN, Cem Z\";i:6;s:23:\"HOTAMISLIGIL, G\u00f6khan S\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"SCIEAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:104:\"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:51:\"American Association for the Advancement of Science\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"4\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1128294\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1128294\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:104:\"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes\";s:9:\"\u0000*\u0000jtitle\";s:26:\"Science (Washington, D.C.)\";s:9:\"\u0000*\u0000stitle\";s:20:\"Science (Wash. D.C.)\";s:7:\"\u0000*\u0000date\";s:4:\"2006\";s:9:\"\u0000*\u0000volume\";s:3:\"313\";s:8:\"\u0000*\u0000issue\";s:4:\"5790\";s:8:\"\u0000*\u0000spage\";s:4:\"1137\";s:8:\"\u0000*\u0000epage\";s:4:\"1140\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0036-8075\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"\u00d6ZCAN\";s:10:\"\u0000*\u0000aufirst\";s:4:\"Umut\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:13:\"YILMAZ, Erkan\";i:1;s:12:\"\u00d6ZCAN, Lale\";i:2;s:17:\"FURUHASHI, Masato\";i:3;s:18:\"VAILLANCOURT, Eric\";i:4;s:13:\"SMITH, Ross O\";i:5;s:15:\"G\u00d6RG\u00dcN, Cem Z\";i:6;s:23:\"HOTAMISLIGIL, G\u00f6khan S\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"SCIEAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:104:\"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:51:\"American Association for the Advancement of Science\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"4\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1128294\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:104:\"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes\";s:9:\"\u0000*\u0000jtitle\";s:26:\"Science (Washington, D.C.)\";s:9:\"\u0000*\u0000stitle\";s:20:\"Science (Wash. D.C.)\";s:7:\"\u0000*\u0000date\";s:4:\"2006\";s:9:\"\u0000*\u0000volume\";s:3:\"313\";s:8:\"\u0000*\u0000issue\";s:4:\"5790\";s:8:\"\u0000*\u0000spage\";s:4:\"1137\";s:8:\"\u0000*\u0000epage\";s:4:\"1140\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0036-8075\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"\u00d6ZCAN\";s:10:\"\u0000*\u0000aufirst\";s:4:\"Umut\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:13:\"YILMAZ, Erkan\";i:1;s:12:\"\u00d6ZCAN, Lale\";i:2;s:17:\"FURUHASHI, Masato\";i:3;s:18:\"VAILLANCOURT, Eric\";i:4;s:13:\"SMITH, Ross O\";i:5;s:15:\"G\u00d6RG\u00dcN, Cem Z\";i:6;s:23:\"HOTAMISLIGIL, G\u00f6khan S\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"SCIEAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:104:\"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:51:\"American Association for the Advancement of Science\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"4\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:23:\"10.1126\/science.1128294\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:104:\"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes\";s:9:\"\u0000*\u0000jtitle\";s:26:\"Science (Washington, D.C.)\";s:9:\"\u0000*\u0000stitle\";s:20:\"Science (Wash. D.C.)\";s:7:\"\u0000*\u0000date\";s:4:\"2006\";s:9:\"\u0000*\u0000volume\";s:3:\"313\";s:8:\"\u0000*\u0000issue\";s:4:\"5790\";s:8:\"\u0000*\u0000spage\";s:4:\"1137\";s:8:\"\u0000*\u0000epage\";s:4:\"1140\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0036-8075\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"\u00d6ZCAN\";s:10:\"\u0000*\u0000aufirst\";s:4:\"Umut\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:13:\"YILMAZ, Erkan\";i:1;s:12:\"\u00d6ZCAN, Lale\";i:2;s:17:\"FURUHASHI, Masato\";i:3;s:18:\"VAILLANCOURT, Eric\";i:4;s:13:\"SMITH, Ross O\";i:5;s:15:\"G\u00d6RG\u00dcN, Cem Z\";i:6;s:23:\"HOTAMISLIGIL, G\u00f6khan S\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"SCIEAS\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:104:\"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:51:\"American Association for the Advancement of Science\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"4\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
