Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals
- Author
- SAXENA, Richa1 2 3 ; GIANNINY, Lauren1 ; LINDBLAD, Ulf4 7 ; DALY, Mark J1 2 5 ; TUOMI, Tiinamaija6 ; HIRSCHHORN, Joel N1 5 8 ; ARDLIE, Kristin G1 9 ; GROOP, Leif C4 6 ; ALTSHULER, David1 2 3 5 ; BURTT, Noël P1 ; LYSSENKO, Valeriya4 ; GIUDUCCI, Candace1 ; SJÖGREN, Marketa4 ; FLOREZ, Jose C1 2 5 ; ALMGREN, Peter4 ; ISOMAA, Bo6 ; ORHO-MELANDER, Marju4
[1] Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
[2] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States
[3] Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States
[4] Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, Malmö, Sweden
[5] Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States
[6] Department of Medicine, Helsinki University Central Hospital, Folkhalsan Genetic Institute, Folkhalsan Research Center and Research Program for Molecular Medicine, University of Helsinki, Helsinki, Finland
[7] Skaraborg Institute, Skövde, Sweden
[8] Divisions of Genetics and Endocrinology, Children's Hospital, Boston, Massachusetts, United States
[9] Genomics Collaborative, Cambridge, Massachusetts, United States - Source
Diabetes (New York, NY). 2006, Vol 55, Num 10, pp 2890-2895, 6 p ; ref : 26 ref
- CODEN
- DIAEAZ
- ISSN
- 0012-1797
- Scientific domain
- Endocrinology; Nutrition, obesity, metabolic disorders
- Publisher
- American Diabetes Association, Alexandria, VA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Diabète type 2 Glucose Homme Insuline Polymorphisme Endocrinopathie Hormone pancréatique Métabolisme pathologie
- Keyword (en)
- Type 2 diabetes Glucose Human Insulin Polymorphism Endocrinopathy Pancreatic hormone Metabolic diseases
- Keyword (es)
- Diabetes de tipo 2 Glucosa Hombre Insulina Polimorfismo Endocrinopatía Hormona pancreática Metabolismo patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance / 002B21E01A Etiopathogenesis. Screening. Investigations. Target tissue resistance
- Discipline
- Endocrinopathies
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18148457
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.2337/db06-0381 
https://dx.doi.org/10.2337/db06-0381
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