A new benzoxazine compound blocks KATP channels in pancreatic β cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo
- Author
- ROLLAND, J-F1 ; TRICARICO, D1 ; LAGHEZZA, A2 ; LOIODICE, F2 ; TORTORELLA, V2 ; CONTE CAMERINO, D1
[1] Department of Pharmacobiology, Unit of Pharmacology, Faculty of Pharmacy, University of Bari, Bari, Italy
[2] Department of Medicinal Chemistry, Faculty of Pharmacy, University of Bari, Bari, Italy - Source
British journal of pharmacology. 2006, Vol 149, Num 7, pp 870-879, 10 p ; ref : 1 p.1/4
- CODEN
- BJPCBM
- ISSN
- 0007-1188
- Scientific domain
- Pharmacology drugs
- Publisher
- Nature Publishing, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- KATP channel Kir6.2AC36 benzoxazine derivative intraperitoneal glucose tolerance test native pancreatic beta cells patch-clamp tsA201 cells
- Keyword (fr)
- Benzoxazine dérivé Hyperglycémie provoquée Hypoglycémiant In vitro In vivo Méthode patch clamp Pancréas Sélectivité Benzooxazine dérivé Electrophysiologie
- Keyword (en)
- Benzoxazine derivatives Glucose tolerance test Hypoglycemic agent In vitro In vivo Patch clamp method Pancreas Selectivity Electrophysiology
- Keyword (es)
- Benzoxazina derivado Hiperglicemia provocada Hipoglicemiante In vitro In vivo Método patch clamp Páncreas Selectividad Electrofisiología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18329684
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.bjp.0706895 
https://dx.doi.org/10.1038/sj.bjp.0706895
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