PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah^enu2 mice

Author

EMBURY, Jennifer E¹ ; CHARRON, Catherine E² ; MARTYNYUK, Anatoly³ ; ZORI, Andreas G¹ ; BIN LIU⁴ ; ALI, Syed F⁵ ; ROWLAND, Neil E⁶ ; LAIPIS, Philip J¹
[1] Department of Biochemistry and Molecular Biology, PO Box 100245, College of Medicine, University of Florida, Gainesville, FL 32610, United States
[2] National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
[3] Department of Anesthesiology, College of Medicine, University of Florida, Gainesville, FL 32610, United States
[4] Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, United States
[5] Neurochemistry Laboratory, National Center for Toxicology Research/FDA, Jefferson, AR 72079, United States
[6] Department of Psychology, College of Liberal of Arts and Sciences, University of Florida, Gainesville, FL 32610, United States

Source

Brain research. 2007, Vol 1127, pp 136-150, 15 p ; ref : 1 p.1/4

CODEN

BRREAP

ISSN

0006-8993

Scientific domain

Neurology; Physiology, morphology

Publisher

Elsevier, Amsterdam / Elsevier, London / Elsevier, New York, NY

Publication country

Netherlands

Document type

Article

Language

English

Author keyword

Adeno-associated virus Gene therapy Monoamines Oxidative stress Phenylketonuria

Keyword (fr)

Age Animal Corps strié Dégénérescence Locus niger Monoamine Phénylcétonurie Précoce Souris Stress oxydatif Thérapie génique Aminoacidopathie Encéphale Enzymopathie Maladie héréditaire Mammalia Métabolisme pathologie Noyau gris central Rodentia Système nerveux central Système nerveux pathologie Vertebrata

Keyword (en)

Age Animal Corpus striatum Degeneration Locus niger Monoamine Phenylketonuria Early Mouse Oxidative stress Gene therapy Aminoacid disorder Encephalon Enzymopathy Genetic disease Mammalia Metabolic diseases Basal ganglion Rodentia Central nervous system Nervous system diseases Vertebrata

Keyword (es)

Edad Animal Cuerpo estriado Degeneración Locus níger Monoamina Fenilcetonuria Precoz Ratón Estrés oxidativo Terapia génica Aminoacido alteración Encéfalo Enzimopatía Enfermedad hereditaria Mammalia Metabolismo patología Núcleo basal Rodentia Sistema nervioso central Sistema nervioso patología Vertebrata

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B22 Metabolic diseases / 002B22D Errors of metabolism / 002B22D01 Aminoacid disorders

Discipline

Metabolic diseases

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

18440178

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS