Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium
- Author
- LE MEUR, G1 2 ; STIEGER, K1 ; ALI, R. R3 ; HAMEL, C7 ; MOULLIER, P1 ; ROLLING, F1 ; SMITH, A. J3 ; WEBER, M1 2 ; DESCHAMPS, J. Y4 ; NIVARD, D1 ; MENDES-MADEIRA, A1 ; PROVOST, N1 ; PEREON, Y5 ; CHEREL, Y6
[1] INSERM U649, CHU Hotel-Dieu, Nantes, France
[2] CHU Hotel-Dieu, Service d'Ophtalmologie, Nantes, France
[3] Division of Molecular Therapy, Institute of Ophthalmology, University College of London, London, United Kingdom
[4] Ecole Nationale Veterinaire de Nantes, Service d'urgences, Nantes, France
[5] CHU Hotel-Dieu, Laboratoire d'Exploration fonctionnelle, Nantes, France
[6] INRA UMR 703, Ecole Nationale Vétérinaire de Nantes, Nantes, France
[7] INSERM U583, Hôpital Saint-Eloi, Institut des Neurosciences de Montpellier, Montpellier, France - Source
Gene therapy (Basingstoke). 2007, Vol 14, Num 4, pp 292-303, 12 p ; ref : 34 ref
- ISSN
- 0969-7128
- Scientific domain
- Biotechnology; Genetics; Pharmacology drugs
- Publisher
- Nature Publishing Group, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- AAV4 Leber congenital amaurosis RPE65 canine model early onset retinal dystrophy retina
- Keyword (fr)
- Chien Congénital Dependovirus Dystrophie Dégénérescence neurorétinienne héréditaire Leber Epithélium pigmentaire Modèle Précoce Restauration Rétine Sérotype Thérapie génique Vecteur Vision Appareil visuel Carnivora Fissipedia Maladie héréditaire Mammalia Oeil pathologie Parvoviridae Parvovirinae Rétinopathie Vertebrata Virus
- Keyword (en)
- Dog Congenital Dependovirus Dystrophy Leber amaurosis Pigment epithelium Models Early Restoration Retina Serotype Gene therapy Vector Vision Visual system Carnivora Fissipedia Genetic disease Mammalia Eye disease Parvoviridae Parvovirinae Retinopathy Vertebrata Virus
- Keyword (es)
- Perro Congénito Dependovirus Distrofia Degeneración neuroretiniana hereditaria Leber Epitelio pigmentario Modelo Precoz Restauración Retina Serotipo Terapia génica Vector Visión Aparato visual Carnivora Fissipedia Enfermedad hereditaria Mammalia Ojo patología Parvoviridae Parvovirinae Retinopatía Vertebrata Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology / 002A31D Industrial applications and implications. Economical aspects / 002A31D01 Health. Pharmaceutical industry / 002A31D01D Gene therapy
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B09 Ophthalmology / 002B09I Retinopathies
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B27 Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy / 002B27D Transfusions. Complications. Transfusion reactions. Cell and gene therapy / 002B27D03 Applied cell therapy and gene therapy
- Discipline
- Anaesthesia. Reanimation. Transfusion. Cell therapy and gene therapy Biotechnology Ophthalmology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18519266
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.gt.3302861 
https://dx.doi.org/10.1038/sj.gt.3302861
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