Structural simplification of bioactive natural products with multicomponent synthesis : Dihydropyridopyrazole analogues of podophyllotoxin
- Author
- MAGEDOV, Igor V1 2 ; MANPADI, Madhuri3 ; ROZHKOVA, Elena1 ; PRZHEVAL'SKII, Nikolai M1 ; ROGELJ, Snezna4 ; SHORS, Scott T4 ; STEELANT, Wim F. A3 ; VAN SLAMBROUCK, Severine3 ; KORNIENKO, Alexander3
[1] Department of Organic Chemistry, Timiryazev Agriculture Academy, Moscow 127550, Russian Federation
[2] Intelbioscan Ltd., Timiryazevsky Proesd 2, Moscow 127550, Russian Federation
[3] Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, NM 87801, United States
[4] Department of Biology, New Mexico Institute of Mining and Technology, Socorro, NM 87801, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 5, pp 1381-1385, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- Russian
- Author keyword
- Antimitotic agents Multicomponent synthesis Podophyllotoxin
- Keyword (fr)
- Anticancéreux Antimitotique Apoptose Cellule tumorale Chimiothèque Col utérus Composé aromatique Composé tricyclique Cytotoxicité Glande mammaire Homme In vitro Lactone Lignée HeLa Lignée cellulaire Lymphocyte T Podophyllotoxine Relation structure activité Synthèse chimique Furo[3,4-b]pyrazolo[4,3-e]pyridin-5-one dérivé Furo[3,4-b]pyrazolo[4,3-e]pyridine dérivé Furopyrazolopyridine Lignée JURKAT Lignée MCF7
- Keyword (en)
- Antineoplastic agent Antimitotic Apoptosis Tumor cell Chemical compound library Uterine cervix Aromatic compound Tricyclic compound Cytotoxicity Mammary gland Human In vitro Lactone Hela cell line Cell line T-Lymphocyte Structure activity relation Chemical synthesis
- Keyword (es)
- Anticanceroso Antimitótico Apoptosis Célula tumoral Quimioteca Cuello útero Compuesto aromático Compuesto tricíclico Citotoxicidad Glándula mamaria Hombre In vitro Lactona Célula HeLa Línea celular Linfocito T Relación estructura actividad Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18573762
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2006.11.095 
https://dx.doi.org/10.1016/j.bmcl.2006.11.095
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