A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis
- Author
- MIYAMOTO, Yoshinari1 ; MABUCHI, Akihiko1 ; OZAKI, Koichi8 ; TAKIGAWA, Masaharu9 ; TANAKA, Toshihiro8 ; NAKAMURA, Yusuke10 ; QING JIANG2 ; IKEGAWA, Shiro1 ; DONGQUAN SHI2 ; KUBO, Toshikazu3 ; TAKATORI, Yoshio4 ; SAITO, Susumu5 ; FUJIOKA, Mikihiro3 ; SUDO, Akihiro6 ; UCHIDA, Atsumasa6 ; YAMAMOTO, Seizo7
[1] Laboratory for Bone and Joint Diseases, SNP Research Center, RIKEN, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
[2] The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital affiliated with the Medical School of Nanjing University, Zhongshan Road 321, Nanjing 210008, Jiangsu, China
[3] Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
[4] Department of Orthopaedic Surgery, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
[5] Department of Orthopaedic Surgery, Sumitomo Hospital, Nakanoshima 5-3-20, Kita-ku, Osaka 530-0005, Japan
[6] Department of Orthopaedic Surgery, Mie University Faculty of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan
[7] Department of Orthopedic Surgery, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
[8] Laboratory for Cardiovascular Diseases, SNP Research Center, RIKEN, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
[9] Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 5-1-2 Shikata-cho, Okayama 700-8525, Japan
[10] Laboratory for Genotyping, SNP Research Center, RIKEN, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan - Source
Nature genetics. 2007, Vol 39, Num 4, pp 529-533, 5 p ; ref : 30 ref
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Arthrose Polymorphisme Association génétique Arthropathie Maladie dégénérative Système ostéoarticulaire pathologie
- Keyword (en)
- Osteoarthritis Polymorphism Arthropathy Degenerative disease Diseases of the osteoarticular system
- Keyword (es)
- Artrosis Polimorfismo Artropatía Enfermedad degenerativa Sistema osteoarticular patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15E Osteoarthritis
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15I Miscellaneous. Osteoarticular involvement in other diseases
- Discipline
- Eukaryotes genetics. Biological and molecular evolution Osteoarticular pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18673213
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/2005 
https://dx.doi.org/10.1038/2005
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