Inhibition of p38α mitogen-activated protein kinase prevents the development of osteolytic bone disease, reduces tumor burden, and increases survival in murine models of multiple myeloma
- Author
- VANDERKERKEN, Karin1 ; MEDICHERLA, Satya2 ; CROUCHER, Peter I3 ; COULTON, Les3 ; DE RAEVE, Hendrik4 ; WILLEMS, Angelo1 ; LAWSON, Michelle3 ; VAN CAMP, Ben1 ; PROTTER, Andrew A2 ; HIGGINS, Linda S2 ; MENU, Eline1
[1] Department of Hematology and Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium
[2] Scios, Inc, Fremont, California, United States
[3] Academic Unit of Bone Biology, University of Sheffield School of Medicine and Biomedical Science, Sheffield, United Kingdom
[4] Department of Pathology, University Hospital Antwerp, Antwerp, Belgium - Source
Cancer research (Baltimore). 2007, Vol 67, Num 10, pp 4572-4577, 6 p ; ref : 13 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Inhibiteur enzyme Mitogen-activated protein kinase Modèle animal Myélome Ostéolyse Prévention Souris Survie Système ostéoarticulaire pathologie Tumeur osseuse Enzyme Hémopathie maligne Immunoglobulinopathie Immunopathologie Lymphoprolifératif syndrome Mammalia Rodentia Vertebrata
- Keyword (en)
- Enzyme inhibitor Mitogen-activated protein kinase Animal model Myeloma Osteolysis Prevention Mouse Survival Diseases of the osteoarticular system Bone tumor Enzyme Malignant hemopathy Immunoglobulinopathy Immunopathology Lymphoproliferative syndrome Mammalia Rodentia Vertebrata
- Keyword (es)
- Inhibidor enzima Mitogen-activated protein kinase Modelo animal Mieloma Osteólisis Prevención Ratón Sobrevivencia Sistema osteoarticular patología Enzima Hemopatía maligna Inmunoglobulinopatía Inmunopatología Linfoproliferativo síndrome Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B06 Immunopathology / 002B06D Immunodeficiencies. Immunoglobulinopathies / 002B06D02 Immunoglobulinopathies
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15A Osteoporosis. Osteomalacia. Paget disease
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15C Tumors of striated muscle and skeleton
- Discipline
- Immunopathology Osteoarticular pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18808121
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1158/0008-5472.CAN-06-4361 
https://dx.doi.org/10.1158/0008-5472.CAN-06-4361
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