Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
- Author
- FURUHASHI, Masato1 ; TUNCMAN, Gürol1 ; SULSKY, Richard3 ; ROBL, Jeffrey A3 ; PARKER, Rex A3 ; HOTAMISLIGIL, Gökhan S1 ; GÖRGÜN, Cem Z1 ; MAKOWSKI, Liza1 ; ATSUMI, Genichi1 ; VAILLANCOURT, Eric1 ; KONO, Keita1 ; BABAEV, Vladimir R2 ; FAZIO, Sergio2 ; LINTON, Macrae F2
[1] Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, United States
[2] Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
[3] Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, United States - Source
Nature (London). 2007, Vol 447, Num 7147, pp 959-965, 7 p ; ref : 26 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide gras Adipocyte Animal Athérosclérose Cible Diabète type 2 Déficit Grave Inflammation Lignée cellulaire Lipide Macrophage Modèle animal Mécanisme action Métabolisme pathologie Protéine liaison Souris Spécificité Traitement Voie orale X Syndrome Forme grave Appareil circulatoire pathologie Endocrinopathie Mammalia Rodentia Vaisseau sanguin pathologie Vertebrata
- Keyword (en)
- Fatty acids Adipocyte Animal Atherosclerosis Target Type 2 diabetes Deficiency Severe Inflammation Cell line Lipids Macrophage Animal model Mechanism of action Metabolic diseases Binding protein Mouse Specificity Treatment Oral administration X Syndrome Cardiovascular disease Endocrinopathy Mammalia Rodentia Vascular disease Vertebrata
- Keyword (es)
- Acido graso Adipocito Animal Ateroesclerosis Blanco Diabetes de tipo 2 Déficiencia Grave Inflamación Línea celular Lípido Macrófago Modelo animal Mecanismo acción Metabolismo patología Proteína enlace Ratón Especificidad Tratamiento Vía oral X Síndrome Aparato circulatorio patología Endocrinopatía Mammalia Rodentia Vaso sanguíneo patología Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B12 Cardiology. Vascular system / 002B12B Blood and lymphatic vessels / 002B12B01 Atherosclerosis (general aspects, experimental research)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance / 002B21E01A Etiopathogenesis. Screening. Investigations. Target tissue resistance
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B22 Metabolic diseases / 002B22E Other metabolic disorders / 002B22E05 Miscellaneous
- Discipline
- Cardiology. Circulatory system Endocrinopathies Metabolic diseases
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18837775
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature05844 
https://dx.doi.org/10.1038/nature05844
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