Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects
- Author
- STONE, Nimalie D1 ; DUNAWAY, Shelia B2 ; PARK, Jeong-Gun3 ; LALAMA, Christina3 ; SNYDER, Sally5 ; KALLUNGAL, Beatrice5 ; KLINGMAN, Karin L6 ; HENDRIX, Craig W1 ; FLEXNER, Charles1 ; TIERNEY, Camlin3 ; CALANDRA, Gary B4 ; BECKER, Stephen4 ; CAO, Ying-Jun1 ; WIGGINS, Ilene P1 ; CONLEY, Jeanne2 ; MACFARLAND, Ron T4
[1] Johns Hopkins University School of Medicine, Division of Clinical Pharmacology, Harvey 502, 600 N. Wolfe St, Baltimore, Maryland, United States
[2] University of Washington School of Medicine and Harborview Medical Center, 325 9th Avenue, Box 359929, Seattle, Washington 98104, United States
[3] Harvard School of Public Health, Boston, Massachusetts, United States
[4] AnorMED, Inc., 200-20353 64th Ave, Langley, British Columbia, V2Y 1N55, Canada
[5] Social and Scientific Systems, Inc, Silver Spring, Maryland, United States
[6] Division of AIDS, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States - Source
Antimicrobial agents and chemotherapy. 2007, Vol 51, Num 7, pp 2351-2358, 8 p ; ref : 12 ref
- CODEN
- AACHAX
- ISSN
- 0066-4804
- Scientific domain
- Microbiology, infectious diseases; Pharmacology drugs
- Publisher
- American Society for Microbiology, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Dose croissante Dose répétée Homme Inhibiteur Pharmacocinétique Récepteur chimiokine CXCR4 Toxicité Voie orale
- Keyword (en)
- Biological activity Increasing dose Multiple dose Human Inhibitor Pharmacokinetics CXCR4 chemokine receptor Toxicity Oral administration
- Keyword (es)
- Actividad biológica Dosis creciente Dosis múltiple Hombre Inhibidor Farmacocinética Receptor quimioquina CXCR4 Toxicidad Vía oral
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 18893993
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1128/AAC.00013-07 
https://dx.doi.org/10.1128/AAC.00013-07
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