LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake
- Author
- ZHENG ZHOU1 ; JUAN ZHEN2 ; KARPOWICH, Nathan K1 ; GOETZ, Regina M1 ; LAW, Christopher J1 ; REITH, Maarten E. A2 ; WANG, Da-Neng1
[1] Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, United States
[2] Departments of Psychiatry and Pharmacology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, United States - Source
Science (Washington, D.C.). 2007, Vol 317, Num 5843, pp 1390-1393, 4 p ; ref : 29 ref
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antidépresseur Composé tricyclique Désipramine Homme Inhibition présynaptique Leucine Membrane plasmique Modélisation Mécanisme action Psychotrope Site action Site fixation Structure 3 dimensions Structure cristalline Aminoacide Dibenzoazépine dérivé Inhibiteur recapture Noradrénaline
- Keyword (en)
- Antidepressant agent Tricyclic compound Desipramine Human Presynaptic inhibition Leucine Plasma membrane Modeling Mechanism of action Psychotropic Site of action Binding site Three dimensional structure Crystalline structure Aminoacid Dibenzazepine derivatives Reuptake inhibitor Norepinephrine
- Keyword (es)
- Antidepresor Compuesto tricíclico Desipramina Hombre Inhibición presináptica Leucina Membrana plasmática Modelización Mecanismo acción Psicotropo Lugar acción Sitio fijación Estructura 3 dimensiones Estructura cristalina Aminoácido Dibenzoazepina derivado Inhibidor recaptura Noradrenalina
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 19081984
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1126/science.1147614 
https://dx.doi.org/10.1126/science.1147614
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