Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
- Author
- STOMMEL, Jayne M1 ; KIMMELMAN, Alec C1 2 ; CHIN, Lynda1 3 7 ; DEPINHO, Ronald A1 3 8 ; HAOQIANG YING1 ; NABIOULLIN, Roustem3 ; PONUGOTI, Aditya H3 ; WIEDEMEYER, Ruprecht1 ; STEGH, Alexander H1 ; BRADNER, James E4 ; LIGON, Keith L1 5 ; BRENNAN, Cameron6
[1] Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, United States
[2] Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, United States
[3] Center for Applied Cancer Science, Betfer Institute for Innovative Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02115, United States
[4] Division of Hematologic Neoplasia, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, United States
[5] Department of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Boston, MA 02115, United States
[6] Departments of Neurosurgery, Memorial Sloan Kettering Cancer Center and Neurological Surgery, Weill Medical College of Cornell University, New York, NY 10021, United States
[7] Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States
[8] Departments of Medicine and Genetics, Harvard Medical School, Boston, MA 02115, United States - Source
Science (Washington, D.C.). 2007, Vol 318, Num 5848, pp 287-290, 4 p ; ref : 22 ref
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- 1-Phosphatidylinositol 3-kinase Activité Anticancéreux Cellule cible Cellule tumorale Ciblage Cible Déficit Glioblastome multiforme Hétérotransplantation Lignée cellulaire Multiple Multiplication cellulaire Protein-tyrosine kinase Réponse Survie Thérapie cellulaire Traitement associé Tumeur intracrânienne Tumeur maligne Tumeur solide Interférence ARN Chirurgie Encéphale pathologie Enzyme Gliome malin Greffe Système nerveux central pathologie Système nerveux pathologie Transferases Transplantation
- Keyword (en)
- 1-Phosphatidylinositol 3-kinase Activity Antineoplastic agent Target cell Tumor cell Targeting Target Deficiency Glioblastoma multiforme Heterotransplantation Cell line Multiple Cell proliferation Protein-tyrosine kinase Response Survival Cell therapy Combined treatment Intracranial tumor Malignant tumor Solid tumor RNA interference Surgery Cerebral disorder Enzyme Malignant glioma Graft Central nervous system disease Nervous system diseases Transferases Transplantation
- Keyword (es)
- 1-Phosphatidylinositol 3-kinase Actividad Anticanceroso Célula blanco Célula tumoral Blancado Blanco Déficiencia Glioblastoma multiforme Heterotrasplante Línea celular Múltiple Multiplicación celular Protein-tyrosine kinase Respuesta Sobrevivencia Terapia celular Tratamiento asociado Tumor intracraneal Tumor maligno Tumor sólido Cirugía Encéfalo patología Enzima Glioma maligno Injerto Sistema nervosio central patología Sistema nervioso patología Transferases Trasplantación
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04C Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17E Tumors of the nervous system. Phacomatoses
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B27 Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy / 002B27D Transfusions. Complications. Transfusion reactions. Cell and gene therapy / 002B27D03 Applied cell therapy and gene therapy
- Discipline
- Anaesthesia. Reanimation. Transfusion. Cell therapy and gene therapy Neurology Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19189991
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1126/science.1142946 
https://dx.doi.org/10.1126/science.1142946
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