Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability
- Author
- SANZ, M.-J1 2 ; CORTIJO, J1 2 3 ; HATZELMANN, A5 ; MORCILLO, E. J1 2 7 ; TAHA, M. A1 ; CERDA-NICOLAS, M2 4 ; SCHATTON, E5 ; BURGBACHER, B5 ; KLAR, J5 ; TENOR, H5 ; SCHUDT, C5 ; ISSEKUTZ, A. C6
[1] Department of Pharmacology, University of Valencia, Valencia, Spain
[2] Ciber CB06/06/0027 'Respiratory Diseases', Carlos III Health Institute, Spanish Ministry of Health, Madrid, Spain
[3] Research Foundation, University General Hospital Consortium, University of Valencia, Valencia, Spain
[4] Department of Pathology, University of Valencia, Valencia, Spain
[5] Department of Biochemistry, Nycomed GmbH, Konstanz, Germany
[6] Division of Immunology, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
[7] Clinical Pharmacology Unit, University Clinical Hospital, University of Valencia, Valencia, Spain - Source
British journal of pharmacology. 2007, Vol 152, Num 4, pp 481-492, 12 p ; ref : 1 p.3/4
- CODEN
- BJPCBM
- ISSN
- 0007-1188
- Scientific domain
- Pharmacology drugs
- Publisher
- Nature Publishing, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- E-selectin P-selectin PDE4 endothelial permeability intravital microscopy leukocyte-endothelial interaction roflumilast
- Keyword (fr)
- Antiasthmatique Cellule endothéliale Endothélium Interaction Leucocyte Microcirculation Perméabilité Protéine CAM Roflumilast Sélectine E Sélectine P Inhibiteur de la phosphodiesterase Inhibiteur de la phosphodiestérase 4 3',5'-Cyclic-nucleotide phosphodiesterase Enzyme Esterases Hydrolases Inhibiteur enzyme Phosphoric diester hydrolases
- Keyword (en)
- Antiasthma agent Endothelial cell Endothelium Interaction Leukocyte Microcirculation Permeability Cell adhesion molecule Roflumilast E Selectin P Selectin 3',5'-Cyclic-nucleotide phosphodiesterase Enzyme Esterases Hydrolases Enzyme inhibitor Phosphoric diester hydrolases
- Keyword (es)
- Agente antiasma Célula endotelial Endotelio Interacción Leucocito Microcirculación Permeabilidad Proteína CAM Roflumilast Selectin E Selectin P 3',5'-Cyclic-nucleotide phosphodiesterase Enzima Esterases Hydrolases Inhibidor enzima Phosphoric diester hydrolases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19221764
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.bjp.0707428 
https://dx.doi.org/10.1038/sj.bjp.0707428
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