The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
- Author
- GERKEN, Thomas1 ; GIRARD, Christophe A2 ; GALVANOVSKIS, Juris5 ; RORSMAN, Patrik5 ; ROBINS, Peter6 ; PRIEUR, Xavier3 ; COLL, Anthony P3 ; MA, Marcella3 ; JOVANOVIC, Zorica3 ; SADAF FAROOQI, I3 ; SEDGWICK, Barbara6 ; BARROSO, Inês7 ; LORAINE TUNG, Yi-Chun3 ; LINDAHL, Tomas6 ; PANTING, Chris P8 ; ASHCROFT, Frances M2 ; O'RAHILLY, Stephen3 ; SCHOFIELD, Christopher J1 ; WEBBY, Celia J1 ; SAUDEK, Vladimir3 ; HEWITSON, Kirsty S1 4 ; YEO, Giles S. H3 ; MCDONOUGH, Michael A1 ; CUNLIFFE, Sharon4 ; MCNEILL, Luke A1 4
[1] Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon 0X1 3TA, United Kingdom
[2] Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, Oxon OX1 3PT, United Kingdom
[3] University of Cambridge, Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom
[4] Re0x Ltd., Magdalen Centre, The Oxford Science Park, Oxford, Oxon 0X4 4GA, United Kingdom
[5] Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, Oxon 0X3 7L], United Kingdom
[6] Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
[7] Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
[8] MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, Oxon 0X1 30X, United Kingdom - Source
Science (Washington, D.C.). 2007, Vol 318, Num 5855, pp 1469-1472, 4 p ; ref : 30 ref
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide nucléique DNA monocaténaire Déméthylation Etat nutritionnel Indice masse corporelle Modèle animal Obésité Souris Gène FTO Mammalia Rodentia Trouble de la nutrition Vertebrata
- Keyword (en)
- Nucleic acid Single stranded DNA Demethylation Nutritional status Body mass index Animal model Obesity Mouse Mammalia Rodentia Nutrition disorder Vertebrata
- Keyword (es)
- Acido nucleico DNA monocatenario Desmetilación Estado nutricional Indice masa corporal Modelo animal Obesidad Ratón Mammalia Rodentia Trastorno nutricíon Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution / 002A07C Classical genetics, quantitative genetics, hybrids / 002A07C01 Animals / 002A07C01B Vertebrata
- Discipline
- Eukaryotes genetics. Biological and molecular evolution
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 19896983
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1126/science.1151710 
https://dx.doi.org/10.1126/science.1151710
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