A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

Author

WEIWEI FAN^{1 2} ; WAYMIRE, Katrina G^{1 2} ; NARULA, Navneet³ ; PENG LI⁴ ; ROCHER, Christophe^{1 2} ; COSKUN, Pinar E^{1 2} ; VANNAN, Mani A⁴ ; NARULA, Jagat⁴ ; MACGREGOR, Grant R^{1 5 6} ; WALLACE, Douglas C^{1 2 7}
[1] Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92697, United States
[2] Department of Biological Chemistry, University of California, Irvine, CA 92697, United States
[3] Department of Pathology, University of California, Irvine, CA 92697, United States
[4] Division of Cardiology, Department of Medicine, University of California, Irvine, CA 92697, United States
[5] Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, United States
[6] Developmental Biology Center, University of California, Irvine, CA 92697, United States
[7] Departments of Ecology and Evolutionary Biology and Pediatrics, University of California, Irvine, CA 92697, United States

Source

Science (Washington, D.C.). 2008, Vol 319, Num 5865, pp 958-962, 5 p

CODEN

SCIEAS

ISSN

0036-8075

Scientific domain

Multidisciplinary

Publisher

American Association for the Advancement of Science, Washington, DC

Publication country

United States

Document type

Article

Language

English

Keyword (fr)

Cytopathie mitochondriale DNA mitochondrial Lignée germinale Modèle animal Mutation Souris Sélection Enzymopathie Maladie héréditaire Maladie métabolique Mammalia Rodentia Vertebrata

Keyword (en)

Mitochondrial disorder Mitochondrial DNA Germ line Animal model Mutation Mouse Selection Enzymopathy Genetic disease Metabolic diseases Mammalia Rodentia Vertebrata

Keyword (es)

Citopatía mitocondrial DNA mitocondrial Línea germinal Modelo animal Mutación Ratón Selección Enzimopatía Enfermedad hereditaria Metabolismo patología Mammalia Rodentia Vertebrata

Classification

Pascal

002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution / 002A07C Classical genetics, quantitative genetics, hybrids / 002A07C01 Animals / 002A07C01B Vertebrata

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B22 Metabolic diseases / 002B22D Errors of metabolism / 002B22D05 Miscellaneous hereditary metabolic disorders

Discipline

Eukaryotes genetics. Biological and molecular evolution Metabolic diseases

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

20210918

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS