MTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes
- Author
- FRAENKEL, Merav1 ; KETZINEL-GILAD, Mali1 ; LEIBOWITZ, Gil1 ; ARIAV, Yafa1 ; PAPPO, Orit2 ; KARACA, Melis3 ; CASTEL, Julien3 ; BERTHAULT, Marie-France3 ; MAGNAN, Christophe3 ; CERASI, Erol1 ; KAISER, Nurit1
[1] Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
[2] Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
[3] Laboratoire de Physiopathologie de la Nutrition, Centre National de la Recherche Scientifique Unité Mixte de Recherche, Universiteì Paris, Paris, France - Source
Diabetes (New York, NY). 2008, Vol 57, Num 4, pp 945-957, 13 p ; ref : 51 ref
- CODEN
- DIAEAZ
- ISSN
- 0012-1797
- Scientific domain
- Endocrinology; Nutrition, obesity, metabolic disorders
- Publisher
- American Diabetes Association, Alexandria, VA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Adaptation Cellule β Diabète de type 2 Hyperglycémie Inhibition Endocrinopathie Ilot Langerhans Maladie métabolique Pancréas endocrine
- Keyword (en)
- Adaptation β Cell Type 2 diabetes Hyperglycemia Inhibition Endocrinopathy Langerhans islet Metabolic diseases Endocrine pancreas
- Keyword (es)
- Adaptación Célula β Diabetes de tipo 2 Hiperglicemia Inhibición Endocrinopatía Isla Langerhans Metabolismo patología Páncreas endocrino
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance / 002B21E01A Etiopathogenesis. Screening. Investigations. Target tissue resistance
- Discipline
- Endocrinopathies
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20228098
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.2337/db07-0922 
https://dx.doi.org/10.2337/db07-0922
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