Semi-mechanistic Pharmacokinetic/Pharmacodynamic Modelling of the Antinociceptive Response in the Presence of Competitive Antagonism : The Interaction Between Tramadol and its Active Metabolite on μ-Opioid Agonism and Monoamine Reuptake Inhibition, in the Rat
- Author
- BEIER, Horst1 ; GARRIDO, Maria J2 ; CHRISTOPH, Thomas3 ; KASEL, Dirk1 ; TROCONIZ, Inaki F2
[1] Department of Pharmacokinetics, Grünenthal GmbH, 52078, Aachen, Germany
[2] Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Apartado 177, Pamplona, 31080, Spain
[3] Department of Pharmacology, Grünenthal GmbH, 52078, Aachen, Germany - Source
Pharmaceutical research. 2008, Vol 25, Num 8, pp 1789-1797, 9 p ; ref : 34 ref
- CODEN
- PHREEB
- ISSN
- 0724-8741
- Scientific domain
- Pharmacology drugs
- Publisher
- Springer, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- neuropathic pain racemic tramadol rat model semi-mechanistic pharmacokinetic/ pharmacodynamic model
- Keyword (fr)
- Activité biologique Analgésique Animal Douleur neuropathique Interaction Modélisation Monoamine Métabolite Névralgie Opiacés Pharmacocinétique Racémique Rat Relation pharmacocinétique pharmacodynamie Technologie pharmaceutique Tramadol Mammalia Pathologie du système nerveux Rodentia Trouble neurologique Vertebrata
- Keyword (en)
- Biological activity Analgesic Animal Neuropathic pain Interaction Modeling Monoamine Metabolite Neuralgia Opiates Pharmacokinetics Racemic Rat Pharmacokinetic pharmacodynamic relationship Pharmaceutical technology Tramadol Mammalia Nervous system diseases Rodentia Neurological disorder Vertebrata
- Keyword (es)
- Actividad biológica Analgésico Animal Dolor neuropática Interacción Modelización Monoamina Metabolito Neuralgia Opiados Farmacocinética Racémico Rata Relación farmacocinética farmacodinamia Tecnología farmacéutica Tramadol Mammalia Sistema nervioso patología Rodentia Trastorno neurológico Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A03 Pharmaceutical technology. Pharmaceutical industry
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20534831
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s11095-007-9489-8 
https://dx.doi.org/10.1007/s11095-007-9489-8
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