Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

JUNUTULA, Jagath R; RAAB, Helga; YANMEI LU; MENG, Y. Gloria; NG, Carl; JIHONG YANG

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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Author

JUNUTULA, Jagath R¹ ; RAAB, Helga¹ ; YANMEI LU¹ ; MENG, Y. Gloria¹ ; NG, Carl¹ ; JIHONG YANG¹ ; LEE, Chien C¹ ; DUENAS, Eileen¹ ; GORRELL, Jeffrey¹ ; KATTA, Viswanatham¹ ; KIM, Amy¹ ; MCDORMAN, Kevin¹ ; CLARK, Suzanna¹ ; FLAGELLA, Kelly² ; VENOOK, Rayna² ; ROSS, Sarajane² ; SPENCER, Susan D² ; WAI LEE WONG² ; LOWMAN, Henry B² ; VANDLEN, Richard² ; SLIWKOWSKI, Mark X² ; SCHELLER, Richard H² ; POLAKIS, Paul² ; BHAKTA, Sunil¹ ; MALLET, William² ; LEIPOLD, Douglas D¹ ; WEIR, Sylvia¹ ; CHEN, Yvonne¹ ; SIMPSON, Michelle¹ ; SIAO PING TSAI¹ ; DENNIS, Mark S¹
[1] Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States
[2] Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

Source

Nature biotechnology (Print). 2008, Vol 26, Num 8, pp 925-932, 8 p ; ref : 33 ref

CODEN: NABIF9
ISSN: 1087-0156
Scientific domain: Biotechnology

Publisher

Nature Publishing Group, New York, NY

Publication country: United States

Document type

Article

Language: English

Keyword (fr)

Anticancéreux Anticorps Composé conjugué Conjugaison Cystéine Mutagenèse dirigée Médicament Rat Site spécifique Souris Technique phage display Thiol Toxicité Mammalia Rodentia Vertebrata

Keyword (en)

Antineoplastic agent Antibody Conjugated compound Conjugation Cysteine Site directed mutagenesis Drug Rat Site specificity Mouse Phage display Thiol Toxicity Mammalia Rodentia Vertebrata

Keyword (es)

Anticanceroso Anticuerpo Compuesto conjugado Conjugación Cisteína Mutagénesis dirigida Medicamento Rata Sitio específico Ratón Técnica phage display Tiol Toxicidad Mammalia Rodentia Vertebrata

Classification

Pascal: 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology / 002A31D Industrial applications and implications. Economical aspects / 002A31D01 Health. Pharmaceutical industry / 002A31D01C Production of active biomolecules / 002A31D01C4 Antineoplastic drugs. Cytokines

Discipline

Biotechnology

Origin

Inist-CNRS

Database: PASCAL
INIST identifier: 20588437

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

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