In silico prediction of novel phosphodiesterase type-5 inhibitors derived from Sildenafil, Vardenafil and Tadalafil
- Author
- ANTUNES, Joao E1 ; FREITAS, Matheus P1 ; DA CUNHA, Elaine F. F1 ; RAMALHO, Teodorico C1 ; RITTNER, Roberto2
[1] Departamento de Química, Universidade Federal de Lavras-UFLA, CP 3037, 37200-000 Lavras, MG, Brazil
[2] Chemistry Institute, State University of Campinas, P.O. Box 6154, 13084-971 Campinas, SP, Brazil - Source
Bioorganic & medicinal chemistry. 2008, Vol 16, Num 16, pp 7599-7606, 8 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Docking studies Erectile dysfunction MIA-QSAR PDE-5 inhibitors
- Keyword (fr)
- 3',5'-Cyclic-GMP phosphodiesterase Composé bicyclique Dérivé de l'imidazopyridine Dérivé de la pipérazine Dérivé du benzène Hétérocycle azote angulaire Hétérocycle azote Imide Inhibiteur enzyme Isozyme Lactame Modèle moléculaire Modélisation Pathologie de l'érection Pharmacocinétique Prédiction Relation structure activité Sildénafil Sulfonamide Tadalafil Traitement Vardénafil ADME Imidazo[1,5-a]pyridine-1,3-dione dérivé Imidazo[5,1-f][1,2,4]triazine-5,7-dione dérivé Imidazotriazine Inhibiteur PDE5 Pyrazinopyridoindole Pyrido[1,2-a]pyrazine-1,4-dione dérivé Pyridopyrazine Pyrrolo[3,4-d]pyrimidine-5,7-dione dérivé Pyrrolopyrimidine QSAR Enzyme Esterases Hydrolases Phosphoric diester hydrolases
- Keyword (en)
- 3',5'-Cyclic-GMP phosphodiesterase Bicyclic compound Imidazopyridine derivatives Piperazine derivatives Benzene derivatives Angular nitrogen heterocycle Nitrogen heterocycle Imide Enzyme inhibitor Isozyme Lactam Molecular model Modeling Erection disorders Pharmacokinetics Prediction Structure activity relation Sildenafil Sulfonamide Tadalafil Treatment Vardenafil Absorption Distribution Metabolisme Excretion Enzyme Esterases Hydrolases Phosphoric diester hydrolases
- Keyword (es)
- 3',5'-Cyclic-GMP phosphodiesterase Compuesto bicíclico Imidazopiridina derivado Piperazina derivado Benceno derivado Heterociclo nitrógeno angular Heterociclo nitrógeno Imida Inhibidor enzima Isozima Lactamo Modelo molecular Modelización Erección patología Farmacocinética Predicción Relación estructura actividad Sildenafilo Sulfonamida Tadalafilo Tratamiento Vardenafil Enzima Esterases Hydrolases Phosphoric diester hydrolases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02P Genital system. Reproduction
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20635224
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2008.07.022 
https://dx.doi.org/10.1016/j.bmc.2008.07.022
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