Activating mutations in ALK provide a therapeutic target in neuroblastoma
- Author
- GEORGE, Rani E1 ; SANDA, Takaomi1 ; LIQUAN XUE7 ; ZOZULYA, Sergey8 ; GREGOR, Vlad E8 ; WEBB, Thomas R9 ; GRAY, Nathanael S5 ; GILLILAND, D. Gary4 ; DILLER, Lisa1 ; GREULICH, Heidi2 3 ; MORRIS, Stephan W7 ; MEYERSON, Matthew2 3 ; HANNA, Megan2 3 ; LOOK, A. Thomas1 ; FRÖHLING, Stefan4 ; LUTHER, William1 ; JIANMING ZHANG5 ; AHN, Yebin1 ; WENJUN ZHOU5 ; LONDON, Wendy B6 ; MCGRADY, Patrick6
[1] Department of Pediatric Oncology, Harvard Medical School, Boston, Massachusetts 02115, United States
[2] Department of Medical Oncology & Center for Cancer Genome Discovery, Harvard Medical School, Boston, Massachusetts 02115, United States
[3] Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States
[4] Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States
[5] Department of Biological Chemistry and Molecular Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, United States
[6] Children's Oncology Group Statistics and Data Center, University of Florida, Gainesville, Florida 32601, United States
[7] Departments of Pathology and Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States
[8] ChemBridge Research Laboratories Inc, San Diego, California 92127, United States
[9] Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States - Source
Nature (London). 2008, Vol 455, Num 7215, pp 975-978, 4 p ; ref : 27 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Cancérologie Gène Homme Inhibiteur enzyme Mutation Neuroblastome Protein-tyrosine kinase Thérapeutique ciblée Traitement Gène ALK TAE684 Cancer Enzyme Génétique Pathologie du système nerveux sympathique Pathologie du système nerveux Transferases Tumeur maligne
- Keyword (en)
- Antineoplastic agent Cancerology Gene Human Enzyme inhibitor Mutation Neuroblastoma Protein-tyrosine kinase Targeted therapy Treatment Cancer Enzyme Genetics Autonomic neuropathy Nervous system diseases Transferases Malignant tumor
- Keyword (es)
- Anticanceroso Cancerología Gen Hombre Inhibidor enzima Mutación Neuroblastoma Protein-tyrosine kinase Terapéutica dirigida Tratamiento Cáncer Enzima Genética Sistema nervioso simpático patología Sistema nervioso patología Transferases Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17E Tumors of the nervous system. Phacomatoses
- Discipline
- Neurology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20737851
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature07397 
https://dx.doi.org/10.1038/nature07397
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