Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
- Author
- ORHO-MELANDER, Marju1 ; MELANDER, Olle1 ; SHYONG TAI, E9 ; WELCH, Cullan7 ; ARNETT, Donna K10 ; LYSSENKO, Valeriya1 ; LINDHOLM, Eero1 ; SAXENA, Richa2 ; DE BAKKER, Paul I. W2 ; BURTT, Noel2 ; VOIGHT, Benjamin F2 ; HIRSCHHORN, Joel N2 ; GUIDUCCI, Candace2 ; TUCKER, Katherine L11 ; HEDNER, Thomas12 ; TUOMI, Tiinamaija13 14 ; ISOMAA, Bo14 ; ERIKSSON, Karl-Fredrik1 ; TASKINEN, Marja-Riitta13 ; WAHLSTRAND, Björn12 ; HUGHES, Thomas E15 ; PARNELL, Laurence D4 ; LAI, Chao-Qiang4 ; PEREZ-MARTINEZ, Pablo3 4 5 ; BERGLUND, Göran16 ; PELTONEN, Leena17 ; VARTIAINEN, Erkki18 ; JOUSILAHTI, Pekka18 ; HAVULINNA, Aki S18 ; SALOMAA, Veikko18 ; NILSSON, Peter1 ; GROOP, Leif1 13 ; ALTSHULER, David19 2 20 ; ORDOVAS, Jose M4 ; CORELLA, Dolores5 ; KATHIRESAN, Sekar2 21 ; ROOS, Charlotta1 ; TEWHEY, Ryan2 ; RIEDER, Mark J6 ; HALL, Jennifer7 ; ABECASIS, Goncalo8
[1] Department of Clinical Sciences, University Hospital Malmö, Clinical Research Center, Lund University, Malmö, Sweden
[2] Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States
[3] Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain
[4] Nutrition and Genomics Laboratory, Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States
[5] Genetic and Molecular Epidemiology Unit and CIBER Fisiopatología de la Obesidad y Nutrición, School of Medicine University of Valencia, Valencia, Spain
[6] Department of Genome Sciences, University of Washington, Seattle, Washington, United States
[7] Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States
[8] Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, United States
[9] Department of Endocrinology, Singapore General Hospital, Singapore
[10] Dietary Assessment and Epidemiology Research Program, Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States
[11] Department of Epidemiology, University of Alabama, Birmingham, Alabama, United States
[12] Department of Clinical Pharmacology, Sahlgrenska Academy, Göteborg, Sweden
[13] Department of Medicine, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
[14] Folkhälsan Research Center, Helsinki, Finland
[15] Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States
[16] Department of Clinical Sciences, Medicine, Lund University, Maimö, Sweden
[17] Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
[18] Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
[19] Center for Human Genetic Research and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States
[20] Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States
[21] Cardiovascular Disease Prevention Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States - Source
Diabetes (New York, NY). 2008, Vol 57, Num 11, pp 3112-3121, 10 p ; ref : 40 ref
- CODEN
- DIAEAZ
- ISSN
- 0012-1797
- Scientific domain
- Endocrinology; Nutrition, obesity, metabolic disorders
- Publisher
- American Diabetes Association, Alexandria, VA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Diabète Glucokinase Glucose Gène Jeûne alimentaire Protéine C réactive Triglycéride Variant Endocrinopathie Enzyme Lipide Transferases
- Keyword (en)
- Diabetes mellitus Glucokinase Glucose Gene Fasting C reactive protein Triglyceride Variant Endocrinopathy Enzyme Lipids Transferases
- Keyword (es)
- Diabetes Glucokinase Glucosa Gen Ayuno alimenticio Proteína reactiva Triglicérido Variante Endocrinopatía Enzima Lípido Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance / 002B21E01A Etiopathogenesis. Screening. Investigations. Target tissue resistance
- Discipline
- Endocrinopathies
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20828884
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.2337/db08-0516 
https://dx.doi.org/10.2337/db08-0516
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arXiv access
