Evidence Why Paroxetine Dose Escalation is Not Effective in Major Depressive Disorder : A Randomized Controlled Trial With Assessment of Serotonin Transporter Occupancy
- Author
- RUHE, Henricus G1 ; BOOIJ, Jan2 ; WEERT, Henk C. V3 ; REITSMA, Johannes B4 ; FRANSEN, Eric J. F5 ; MICHEL, Martin C6 ; SCHENE, Aart H1
[1] Program for Mood Disorders, Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
[2] Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
[3] Department of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
[4] Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
[5] Department of Pharmacy and Clinical Pharmacology, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands
[6] Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands - Source
Neuropsychopharmacology (New York, NY). 2009, Vol 34, Num 4, pp 999-1010, 12 p ; ref : 2 p
- CODEN
- NEROEW
- ISSN
- 0893-133X
- Scientific domain
- Cognition; Neurology; Pharmacology drugs; Psychology, psychopathology, psychiatry
- Publisher
- Nature Publishing Group, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- [123I]β-CIT drug dose-response relationship major depressive disorder paroxetine serotonin transporter SPECT
- Keyword (fr)
- Antidépresseur Essai thérapeutique contrôlé Etat dépressif Evaluation Médicament Paroxétine Photon Psychotrope Tomoscintigraphie Transporteur de la sérotonine Escalade de dose Transporteur sérotonine Dérivé de la pipéridine Inhibiteur recapture Inhibiteur sélectif recapture sérotonine Neurotransmetteur Sérotonine Trouble de l'humeur
- Keyword (en)
- Antidepressant agent Controlled therapeutic trial Depression Evaluation Drug Paroxetine Photon Psychotropic Emission tomography Serotonin transporter Dose escalation Serotonin transporter Piperidine derivatives Reuptake inhibitor Selective serotonin reuptake inhibitor Neurotransmitter Serotonin Mood disorder
- Keyword (es)
- Antidepresor Ensayo terapéutico controlado Estado depresivo Evaluación Medicamento Paroxetina Fotón Psicotropo Tomocentelleografía Transportador de la serotonina Piperidina derivado Inhibidor recaptura Inhibidor selectivo recaptura serotonin Neurotransmisor Serotonina Trastorno humor
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B18 Psychopathology. Psychiatry / 002B18C Adult and adolescent clinical studies / 002B18C07 Mood disorders / 002B18C07A Depression
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-D Psychopathology. Psychiatry / 770-D03 Adult and adolescent clinical studies / 770-D03G Mood disorders / 770-D03G01 Depression
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 21152746
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/npp.2008.148 
https://dx.doi.org/10.1038/npp.2008.148
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